Effects of Quercetin on Muscle-Type Nicotinic Receptor Activation and Desensitization

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Abstract

We have studied, for the first time to our knowledge, the effects of Quercetin (QCT), a natural flavonoid, on the activation and desensitization behavior of the muscle-type nicotinic receptors natively expressed by the TE 671 cell line. The effect of QCT was assessed by means of the patch-clamp technique, in the whole-cell configuration. The application of QCT in the bath solution, at concentrations between 1 and 50 mu M. influenced the whole-cell currents induced by 10 mu M Ach in which regards peak current amplitude, activation and desensitization kinetic. The magnitude of the observed effects depended on the duration of exposure and on the QCT concentration in a non-linear fashion. Our data show that QCT influences the kinetic parameters related to the muscle-type nicotinic receptors activation and desensitization.
Original languageUnknown
Pages (from-to)6062-6071
JournalRomanian Biotechnological Letters
Volume16
Issue number2
Publication statusPublished - 1 Jan 2011

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