Effects of positive airway pressure therapy on cardiovascular and metabolic markers in males with obstructive sleep apnea

A. Feliciano, M.J. Oliveira, A. Cysneiros, C. Martinho, R.P. Reis, D. Penque, P. Pinto, C. Bárbara

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Abstract

Introduction Obstructive sleep apnea syndrome (OSAS) is associated with cardiovascular/metabolic complications. Some analytical parameters (homocysteine, glycemic and lipidic profiles) are recognized markers of these consequences. Limited data is available on the association of these markers and OSAS's severity/response to positive airway pressure therapy (PAP). Material and methods In this prospective study we analyzed polysomnographic and analytical data of male patients admitted to sleep laboratory. The aim was to evaluate metabolic/cardiovascular markers in snorers and OSAS patients, to relate with sleep parameters and PAP response. One-hundred and three patients were included, and 73 (71%) were OSAS patients. OSAS patients were similar to snorers except for higher body mass index (BMI) and dyslipidemia. Severe OSAS patients showed higher glycemia, HbA1c, insulin, and insulin resistance, and lower HDL cholesterol in comparison to mild–moderate (p 
Original languageEnglish
Pages (from-to)193-202
Number of pages10
JournalRevista Portuguesa de Pneumologia
Volume23
Issue number4
DOIs
Publication statusPublished - Jul 2017

Keywords

  • Glucose metabolism
  • HOMA-IR
  • Homocysteine
  • Lipid metabolism
  • Obstructive sleep apnea
  • PAP

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