TY - JOUR
T1 - Effects of inorganic mercury exposure in the alveolar bone of rats: an approach of qualitative and morphological aspects
AU - de Oliveira Nunes, Paula Beatriz
AU - Ferreira, Maria Karolina Martins
AU - Frazão, Deborah Ribeiro
AU - Bittencourt, Leonardo Oliveira
AU - dos Santos Chemelo, Victória
AU - Silva, Márcia Cristina Freitas
AU - Pereira-Neto, Armando Lopes
AU - Albuquerque, Alan Rodrigo Leal
AU - Paz, Simone Patricia Aranha
AU - Angélica, Rômulo Simões
AU - Pessanha, Sofia
AU - Lima, Rafael Rodrigues
N1 - Pró-Reitoria de Pesquisa (PACI/PROPESP/UFPA/ Brazil),
Brazilian National Council for Scientific and Technological Development (CNPq),
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brazil (CAPES) – Finance Cod 001
PY - 2022/1
Y1 - 2022/1
N2 - Background: In comparison to organic mercury (MeHg), the environmental inorganic mercury (IHg) can be found in some skin-lightening cosmestics were considered “harmless” for a long time. However, recent studies have shown that long-term exposure to low doses of IHg may affect biological systems. Therefore, this study investigated the effects of IHg long-term exposure to the alveolar bone of adult rats. Methods: Adult Wistar rats were distributed in control and HgCl2 exposed (0.375 mg/kg/day). After 45 days, the rats were euthanized and both blood and hemimandibles were collected. Total blood Hg levels were measured and both inorganic and organic components of the alveolar bone were determined through XRD and ATR-FTIR. The microstructure of the alveolar bone was assessed by using micro-CT and the morphometric analysis was performed by using stereomicroscopy. Results: Alterations in the physicochemical components of the alveolar bone of exposed animals were observed. The bone changes represented a tissue reaction at the microstructural level, such as bone volume increase. However, no significant dimensional changes (bone height) were observed. Conclusion: Exposure to IHg at this dose can promote microstructural changes and alteration in the organic and inorganic components in the alveolar bone.
AB - Background: In comparison to organic mercury (MeHg), the environmental inorganic mercury (IHg) can be found in some skin-lightening cosmestics were considered “harmless” for a long time. However, recent studies have shown that long-term exposure to low doses of IHg may affect biological systems. Therefore, this study investigated the effects of IHg long-term exposure to the alveolar bone of adult rats. Methods: Adult Wistar rats were distributed in control and HgCl2 exposed (0.375 mg/kg/day). After 45 days, the rats were euthanized and both blood and hemimandibles were collected. Total blood Hg levels were measured and both inorganic and organic components of the alveolar bone were determined through XRD and ATR-FTIR. The microstructure of the alveolar bone was assessed by using micro-CT and the morphometric analysis was performed by using stereomicroscopy. Results: Alterations in the physicochemical components of the alveolar bone of exposed animals were observed. The bone changes represented a tissue reaction at the microstructural level, such as bone volume increase. However, no significant dimensional changes (bone height) were observed. Conclusion: Exposure to IHg at this dose can promote microstructural changes and alteration in the organic and inorganic components in the alveolar bone.
KW - Alveolar bone
KW - Infrared mineral characterization
KW - Inorganic mercury
KW - Mercury chloride
KW - Micro-computed tomography
KW - Rats
UR - http://www.scopus.com/inward/record.url?scp=85123721766&partnerID=8YFLogxK
U2 - 10.7717/peerj.12573
DO - 10.7717/peerj.12573
M3 - Article
C2 - 35127276
AN - SCOPUS:85123721766
SN - 2167-8359
VL - 10
JO - PeerJ
JF - PeerJ
M1 - e12573
ER -