Effects of covid-19 infection during pregnancy and neonatal prognosis: what is the evidence?

Alvaro Francisco Lopes Sousa, Carvalho, Herica Emilia de, Oliveira, Layze Braz de, Schneider, Guilherme, Camargo, Emerson Lucas Silva , Watanabe, Evandro , Andrade, Denise, Carvalho, Ana Fatima , Isabel Amélia Costa Mendes, I Fronteira

Research output: Contribution to journalArticle

Abstract

Background: This study's aims are to assess the current evidence presented in the literature regarding the potential risks of COVID-19 infection among pregnant women and consequent fetal transmission.

Methods: a systematic literature review assessing papers published in the most comprehensive databases in the field of health intended to answer the question, "What are the effects of COVID-19 infection during pregnancy, and what is the neonatal prognosis?"

Results: 49 papers published in 2020 were eligible, presenting low levels of evidence. A total of 755 pregnant women and 598 infants were assessed; more than half of pregnant women had C-sections (379/65%). Only 493 (82%) infants were tested for SARS-CoV-2, nine (2%) of whom tested positive. There is, however, no evidence of vertical transmission based on what has been assessed so far, considering there are knowledge gaps concerning the care provided during and after delivery, as well as a lack of suitable biological samples for testing SARS-CoV-2.

Conclusions: We cannot rule out potential worsening of the clinical conditions of pregnant women infected with SARS-CoV-2, whether the infection is associated with comorbidities or not, due to the occurrence of respiratory disorders, cardiac rhythm disturbances, and acid-base imbalance, among others. We recommend relentless monitoring of all pregnant women in addition to testing them before delivery or the first contact with newborns.
Original languageEnglish
Article number4176
Pages (from-to)4176-4193
Number of pages17
JournalInternational Journal of Environmental Research and Public Health
VolumeVol. 17
Issue numbern.º 11
DOIs
Publication statusPublished - 11 Jun 2020

Keywords

  • COVID-19
  • SARS-CoV-2
  • Pregnancy
  • Fetal transmission
  • Mother-to-child

UN Sustainable Development Goals (SDGs)

  • SDG 3 - Good Health and Well-Being

Fingerprint Dive into the research topics of 'Effects of covid-19 infection during pregnancy and neonatal prognosis: what is the evidence?'. Together they form a unique fingerprint.

  • Cite this

    Sousa, A. F. L., Herica Emilia de, C., Layze Braz de, O., Guilherme, S., Emerson Lucas Silva , C., Evandro , W., Denise, A., Ana Fatima , C., Mendes, I. A. C., & Fronteira, I. (2020). Effects of covid-19 infection during pregnancy and neonatal prognosis: what is the evidence? International Journal of Environmental Research and Public Health, Vol. 17(n.º 11), 4176-4193. [4176]. https://doi.org/10.1101/2020.04.17.20069435