TY - JOUR
T1 - Effect of ScCO2 on the decontamination of PECs-based cryogels
T2 - A comparison with H2O steam and H2O2 nebulization methods
AU - Bento, Cristiana S. A.
AU - Carrêlo, Henrique
AU - Alarico, Susana
AU - Empadinhas, Nuno
AU - de Sousa, Hermínio C.
AU - Teresa Cidade, Maria
AU - Braga, Mara E. M.
N1 - Funding Information:
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04539%2F2020/PT#
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04539%2F2020/PT#
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0058%2F2020/PT#
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0037%2F2020/PT#
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50025%2F2020/PT#
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50025%2F2020/PT#
info:eu-repo/grantAgreement/FCT/OE/UI%2FBD%2F151008%2F2021/PT#
info:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F144986%2F2019/PT#
info:eu-repo/grantAgreement/FCT/OE/SFRH%2FBPD%2F108299%2F2015/PT#
This work was financially supported by Fundação para a Ciência e Tecnologia (FCT), Portugal, in the scope of the project STERILAEROGEL – Green method to prepare sterilised biopolymer-based aerogel (POCI-01-0145-FEDER-032625), the Strategic Projects FCT-MEC PEst-C/EQB/UI0102/2019.
Publisher Copyright:
© 2023 The Authors
PY - 2023/11/5
Y1 - 2023/11/5
N2 - Biopolymers present ideal properties to be used in wound dressing solutions. By mixing two oppositely charged macromolecules it is possible to form polyelectrolyte complex (PEC) based cryogels using lyophilization. Their application in the biomedical field is limited due to their sterilization requirements, as conventional methods compromise their physicochemical properties. ScCO2 appears as an alternative method for decontamination. This work assessed several cryogel PEC formulations, chitosan-pectin, gelatine-xanthan gum and alginate-gelatine. PEC formation was confirmed by FTIR and rheological analysis. While steam sterilization compromised cryogels’ chemical and morphological properties, decontamination with scCO2 proved to be a promising method for decontamination of PEC-cryogels, because, similarly to what is observed with hydrogen peroxide, it does not compromise their physicochemical properties.
AB - Biopolymers present ideal properties to be used in wound dressing solutions. By mixing two oppositely charged macromolecules it is possible to form polyelectrolyte complex (PEC) based cryogels using lyophilization. Their application in the biomedical field is limited due to their sterilization requirements, as conventional methods compromise their physicochemical properties. ScCO2 appears as an alternative method for decontamination. This work assessed several cryogel PEC formulations, chitosan-pectin, gelatine-xanthan gum and alginate-gelatine. PEC formation was confirmed by FTIR and rheological analysis. While steam sterilization compromised cryogels’ chemical and morphological properties, decontamination with scCO2 proved to be a promising method for decontamination of PEC-cryogels, because, similarly to what is observed with hydrogen peroxide, it does not compromise their physicochemical properties.
KW - Decontamination
KW - HO steam
KW - HO nebulization
KW - Natural polymers
KW - PECs-based cryogels
KW - scCO
KW - Wound dressing
UR - http://www.scopus.com/inward/record.url?scp=85173150807&partnerID=8YFLogxK
U2 - 10.1016/j.ijpharm.2023.123451
DO - 10.1016/j.ijpharm.2023.123451
M3 - Article
C2 - 37774759
AN - SCOPUS:85173150807
SN - 0378-5173
VL - 646
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
M1 - 123451
ER -