Effect of patients’ expectations on clinical response to fampridine treatment

Filipa Ladeira, Marcelo Mendonça, André Caetano, Manuel Salavisa, Henrique Delgado, Ana Sofia Correia, Miguel Viana-Baptista

Research output: Contribution to journalArticle

1 Citation (Scopus)


Introduction: Patient expectation of treatment outcome is one of the primary mechanisms underlying the placebo effect. In multiple sclerosis trials with symptomatic treatments, a robust placebo effect is observed, which might be related to patient expectations. The aim of this study was to evaluate whether patient expectations regarding fampridine treatment influence the clinical response after 4 weeks and 6 months of treatment. Materials and methods: We designed and carried out a prospective study from June 2015 to August 2017. Before treatment, patients completed a questionnaire including a scale evaluating their expectations regarding the treatment. The effect of baseline positive expectancy on the response status after 4 weeks and 6 months of treatment was analyzed through univariable and, when applicable, multivariable analysis. Results: A total of 47 consecutive patients were included in the study. At week 4, 37 (78.7%) patients were classified as responders; a one-point increase in the positive expectancy questionnaire was significantly associated with a fourfold increase in the likelihood of being a responder [OR = 4.020 (95% CI 1.082–14.933); p = 0.038]. At 6 months, 43 patients completed follow-up. The number of responders decreased to 28; at this point, positive expectancy at baseline was no longer associated with response status. Conclusion: Baseline positive expectancy regarding fampridine was determinant of the clinical response after 4 weeks of treatment. However, in the long term, fampridine efficacy was not dependent on expectations prior to treatment.

Original languageEnglish
Pages (from-to)175-180
Number of pages6
JournalNeurological Sciences
Issue number1
Early online date29 Oct 2018
Publication statusPublished - Jan 2019


  • Beliefs
  • Expectations
  • Fampridine
  • Multiple sclerosis

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