Effect of indoor air quality of day care centers in children with different predisposition for asthma

Pedro Carreiro Martins, Ana Luísa Papoila, Iolanda Caires, Susana Azevedo, Maria Manuela Cano, Daniel Virella, Paula Leiria Pinto, João Paulo Teixeira, José Rosado-Pinto, Isabella Annesi-Maesano, Nuno Neuparth

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


BACKGROUND: Scarce information is available about the relationships between indoor air quality (IAQ) at day care centers (DCC), the estimated predisposition for asthma, and the actual wheezing susceptibility.

METHODS: In the Phase II of ENVIRH study, 19 DCC were recruited after cluster analysis. Children were evaluated firstly using the ISAAC questionnaire and later by a follow-up questionnaire about recent wheezing. A positive asthma predictive index (API) was considered as predisposition for asthma. Every DCC was audited for IAQ and monitored for chemical and biologic contaminants.

RESULTS: We included 1191 children, with a median age of 43 (P25 -P75 : 25-58) months. Considering the overall sample, in the first questionnaire, associations were found between CO2 concentration (increments of 200 ppm) and diagnosis of asthma (OR: 1.10; 95% CI: 1.00-1.20). Each increment of 100 μg/m(3) of total volatile organic compounds (TVOC) and 1 μg of Der p1/g of dust were associated with wheezing in the previous 12 months (OR: 1.06; 95% CI: 1.01-1.11 and OR: 1.06; 95% CI: 0.99-1.12, respectively). In the follow-up questionnaire, TVOC were again associated with wheezing (OR: 1.05; 95% CI: 1.00-1.11). Children exposed to fungal concentration above the 75th percentile had also higher odds of wheezing at follow-up. TVOC were associated with wheezing in children with either negative or positive API.

CONCLUSIONS: IAQ in DCC seems to be associated with wheezing, in children with and without predisposition for asthma.

Original languageEnglish
Pages (from-to)299-306
Number of pages8
JournalPediatric Allergy And Immunology
Issue number3
Publication statusPublished - May 2016


  • asthma
  • asthma predictive index
  • day care center
  • indoor air quality
  • volatile organic compounds
  • wheezing


Dive into the research topics of 'Effect of indoor air quality of day care centers in children with different predisposition for asthma'. Together they form a unique fingerprint.

Cite this