Effect of indoor air quality of day care centers in children with different predisposition for asthma

Pedro Carreiro Martins, Ana Luísa Papoila, Iolanda Caires, Susana Azevedo, Maria Manuela Cano, Daniel Virella, Paula Leiria Pinto, João Paulo Teixeira, José Rosado-Pinto, Isabella Annesi-Maesano, Nuno Neuparth

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

BACKGROUND: Scarce information is available about the relationships between indoor air quality (IAQ) at day care centers (DCC), the estimated predisposition for asthma, and the actual wheezing susceptibility.

METHODS: In the Phase II of ENVIRH study, 19 DCC were recruited after cluster analysis. Children were evaluated firstly using the ISAAC questionnaire and later by a follow-up questionnaire about recent wheezing. A positive asthma predictive index (API) was considered as predisposition for asthma. Every DCC was audited for IAQ and monitored for chemical and biologic contaminants.

RESULTS: We included 1191 children, with a median age of 43 (P25 -P75 : 25-58) months. Considering the overall sample, in the first questionnaire, associations were found between CO2 concentration (increments of 200 ppm) and diagnosis of asthma (OR: 1.10; 95% CI: 1.00-1.20). Each increment of 100 μg/m(3) of total volatile organic compounds (TVOC) and 1 μg of Der p1/g of dust were associated with wheezing in the previous 12 months (OR: 1.06; 95% CI: 1.01-1.11 and OR: 1.06; 95% CI: 0.99-1.12, respectively). In the follow-up questionnaire, TVOC were again associated with wheezing (OR: 1.05; 95% CI: 1.00-1.11). Children exposed to fungal concentration above the 75th percentile had also higher odds of wheezing at follow-up. TVOC were associated with wheezing in children with either negative or positive API.

CONCLUSIONS: IAQ in DCC seems to be associated with wheezing, in children with and without predisposition for asthma.

Original languageEnglish
Pages (from-to)299-306
Number of pages8
JournalPediatric Allergy And Immunology
Volume27
Issue number3
DOIs
Publication statusPublished - May 2016

Fingerprint

Child Day Care Centers
Indoor Air Pollution
Quality of Health Care
Respiratory Sounds
Asthma
Volatile Organic Compounds
Dust
Cluster Analysis
Surveys and Questionnaires

Keywords

  • asthma
  • asthma predictive index
  • day care center
  • indoor air quality
  • volatile organic compounds
  • wheezing

Cite this

Martins, Pedro Carreiro ; Papoila, Ana Luísa ; Caires, Iolanda ; Azevedo, Susana ; Cano, Maria Manuela ; Virella, Daniel ; Pinto, Paula Leiria ; Teixeira, João Paulo ; Rosado-Pinto, José ; Annesi-Maesano, Isabella ; Neuparth, Nuno. / Effect of indoor air quality of day care centers in children with different predisposition for asthma. In: Pediatric Allergy And Immunology. 2016 ; Vol. 27, No. 3. pp. 299-306.
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abstract = "BACKGROUND: Scarce information is available about the relationships between indoor air quality (IAQ) at day care centers (DCC), the estimated predisposition for asthma, and the actual wheezing susceptibility.METHODS: In the Phase II of ENVIRH study, 19 DCC were recruited after cluster analysis. Children were evaluated firstly using the ISAAC questionnaire and later by a follow-up questionnaire about recent wheezing. A positive asthma predictive index (API) was considered as predisposition for asthma. Every DCC was audited for IAQ and monitored for chemical and biologic contaminants.RESULTS: We included 1191 children, with a median age of 43 (P25 -P75 : 25-58) months. Considering the overall sample, in the first questionnaire, associations were found between CO2 concentration (increments of 200 ppm) and diagnosis of asthma (OR: 1.10; 95{\%} CI: 1.00-1.20). Each increment of 100 μg/m(3) of total volatile organic compounds (TVOC) and 1 μg of Der p1/g of dust were associated with wheezing in the previous 12 months (OR: 1.06; 95{\%} CI: 1.01-1.11 and OR: 1.06; 95{\%} CI: 0.99-1.12, respectively). In the follow-up questionnaire, TVOC were again associated with wheezing (OR: 1.05; 95{\%} CI: 1.00-1.11). Children exposed to fungal concentration above the 75th percentile had also higher odds of wheezing at follow-up. TVOC were associated with wheezing in children with either negative or positive API.CONCLUSIONS: IAQ in DCC seems to be associated with wheezing, in children with and without predisposition for asthma.",
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Effect of indoor air quality of day care centers in children with different predisposition for asthma. / Martins, Pedro Carreiro; Papoila, Ana Luísa; Caires, Iolanda ; Azevedo, Susana; Cano, Maria Manuela; Virella, Daniel; Pinto, Paula Leiria; Teixeira, João Paulo; Rosado-Pinto, José; Annesi-Maesano, Isabella; Neuparth, Nuno.

In: Pediatric Allergy And Immunology, Vol. 27, No. 3, 05.2016, p. 299-306.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of indoor air quality of day care centers in children with different predisposition for asthma

AU - Martins, Pedro Carreiro

AU - Papoila, Ana Luísa

AU - Caires, Iolanda

AU - Azevedo, Susana

AU - Cano, Maria Manuela

AU - Virella, Daniel

AU - Pinto, Paula Leiria

AU - Teixeira, João Paulo

AU - Rosado-Pinto, José

AU - Annesi-Maesano, Isabella

AU - Neuparth, Nuno

N1 - © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2016/5

Y1 - 2016/5

N2 - BACKGROUND: Scarce information is available about the relationships between indoor air quality (IAQ) at day care centers (DCC), the estimated predisposition for asthma, and the actual wheezing susceptibility.METHODS: In the Phase II of ENVIRH study, 19 DCC were recruited after cluster analysis. Children were evaluated firstly using the ISAAC questionnaire and later by a follow-up questionnaire about recent wheezing. A positive asthma predictive index (API) was considered as predisposition for asthma. Every DCC was audited for IAQ and monitored for chemical and biologic contaminants.RESULTS: We included 1191 children, with a median age of 43 (P25 -P75 : 25-58) months. Considering the overall sample, in the first questionnaire, associations were found between CO2 concentration (increments of 200 ppm) and diagnosis of asthma (OR: 1.10; 95% CI: 1.00-1.20). Each increment of 100 μg/m(3) of total volatile organic compounds (TVOC) and 1 μg of Der p1/g of dust were associated with wheezing in the previous 12 months (OR: 1.06; 95% CI: 1.01-1.11 and OR: 1.06; 95% CI: 0.99-1.12, respectively). In the follow-up questionnaire, TVOC were again associated with wheezing (OR: 1.05; 95% CI: 1.00-1.11). Children exposed to fungal concentration above the 75th percentile had also higher odds of wheezing at follow-up. TVOC were associated with wheezing in children with either negative or positive API.CONCLUSIONS: IAQ in DCC seems to be associated with wheezing, in children with and without predisposition for asthma.

AB - BACKGROUND: Scarce information is available about the relationships between indoor air quality (IAQ) at day care centers (DCC), the estimated predisposition for asthma, and the actual wheezing susceptibility.METHODS: In the Phase II of ENVIRH study, 19 DCC were recruited after cluster analysis. Children were evaluated firstly using the ISAAC questionnaire and later by a follow-up questionnaire about recent wheezing. A positive asthma predictive index (API) was considered as predisposition for asthma. Every DCC was audited for IAQ and monitored for chemical and biologic contaminants.RESULTS: We included 1191 children, with a median age of 43 (P25 -P75 : 25-58) months. Considering the overall sample, in the first questionnaire, associations were found between CO2 concentration (increments of 200 ppm) and diagnosis of asthma (OR: 1.10; 95% CI: 1.00-1.20). Each increment of 100 μg/m(3) of total volatile organic compounds (TVOC) and 1 μg of Der p1/g of dust were associated with wheezing in the previous 12 months (OR: 1.06; 95% CI: 1.01-1.11 and OR: 1.06; 95% CI: 0.99-1.12, respectively). In the follow-up questionnaire, TVOC were again associated with wheezing (OR: 1.05; 95% CI: 1.00-1.11). Children exposed to fungal concentration above the 75th percentile had also higher odds of wheezing at follow-up. TVOC were associated with wheezing in children with either negative or positive API.CONCLUSIONS: IAQ in DCC seems to be associated with wheezing, in children with and without predisposition for asthma.

KW - asthma

KW - asthma predictive index

KW - day care center

KW - indoor air quality

KW - volatile organic compounds

KW - wheezing

U2 - 10.1111/pai.12521

DO - 10.1111/pai.12521

M3 - Article

VL - 27

SP - 299

EP - 306

JO - Pediatric Allergy And Immunology

JF - Pediatric Allergy And Immunology

SN - 0905-6157

IS - 3

ER -