Effect of EGCG on the DNA in Presence of UV Radiation

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The exposure to ultraviolet (UV) radiation is clearly a current concern since it damages the deoxyribonucleic acid (DNA) and increases the likelihood of developing skin cancer. On the other hand, green tea compounds such as (-)epigallocatechin-3-gallate (EGCG) present several biological properties and, are well-known for its antioxidant activity. The aim of this work is evaluate the effect of the UV radiation on DNA in presence of EGCG molecules. Results of the evolution of the UV-visible spectra with the UV irradiation suggest that EGCG act like an intercalant molecule and a micromolar concentration of EGCG is effective to induce a strong degradation on the DNA pyrimidines bases under UV radiation. This achievement can lead to a novel class of non-binding safe molecules capable of affinity interaction with the DNA as intercalant molecule which can be used as anti-tumor drugs.

Original languageEnglish
Title of host publicationComputational Intelligence Methods for Bioinformatics and Biostatistics - 15th International Meeting, CIBB 2018, Revised Selected Papers
EditorsMaria Raposo, Paulo Ribeiro, Susana Sério, Antonino Staiano, Angelo Ciaramella
Place of PublicationCham
PublisherSpringer
Pages303-308
Number of pages6
ISBN (Electronic)978-3-030-34585-3
ISBN (Print)978-3-030-34584-6
DOIs
Publication statusPublished - 2020
Event15th International Conference on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2018 - Caparica, Portugal
Duration: 6 Sep 20188 Sep 2018

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
PublisherSpringer
Volume11925 LNBI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference15th International Conference on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2018
CountryPortugal
CityCaparica
Period6/09/188/09/18

Keywords

  • DNA
  • EGCG
  • UV radiation

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