TY - GEN
T1 - Effect of chronic caffeine intake on carotid body catecholamine dynamics in control and chronically hypoxic rats
AU - Conde, Silvia V.
AU - Obeso, Ana
AU - Monteiro, Emília C.
AU - Gonzalez, Constancio
PY - 2012
Y1 - 2012
N2 - Caffeine is the most commonly psychoactive drug, an habitual drink in high altitude sporting, and when acutely taken, it causes profound alterations in carotid body (CB) function and ventilation via adenosine receptors antagonism. In the present work we have investigated the effects of chronic caffeine ingestion in catecholamine (CA) dynamics in the carotid body of control and chronic hypoxic rats. Four groups of animals were used: normoxic (N), caffeine-treated normoxic (1 mg/mL in drinking water 15 days; CafN), chronic hypoxic (CH, 12%O2, 15 days) and chronically hypoxic-caffeine-treated (CafH). Caffeine intake in controls rats did not modify CA content, synthesizing, and releasing responses, and the expression of tyrosine hydroxylase. CH increased dopamine content, synthesis, and basal and acute hypoxia-induced release; chronic caffeine ingestion augmented CH effects. Findings indicate that chronic caffeine ingestion in normoxic rats did not modify dopamine dynamics at the CB, but increases dopaminergic system during chronic hypoxia.
AB - Caffeine is the most commonly psychoactive drug, an habitual drink in high altitude sporting, and when acutely taken, it causes profound alterations in carotid body (CB) function and ventilation via adenosine receptors antagonism. In the present work we have investigated the effects of chronic caffeine ingestion in catecholamine (CA) dynamics in the carotid body of control and chronic hypoxic rats. Four groups of animals were used: normoxic (N), caffeine-treated normoxic (1 mg/mL in drinking water 15 days; CafN), chronic hypoxic (CH, 12%O2, 15 days) and chronically hypoxic-caffeine-treated (CafH). Caffeine intake in controls rats did not modify CA content, synthesizing, and releasing responses, and the expression of tyrosine hydroxylase. CH increased dopamine content, synthesis, and basal and acute hypoxia-induced release; chronic caffeine ingestion augmented CH effects. Findings indicate that chronic caffeine ingestion in normoxic rats did not modify dopamine dynamics at the CB, but increases dopaminergic system during chronic hypoxia.
KW - Caffeine
KW - Carotid body
KW - Catecholamines
KW - Chronic hypoxia
UR - http://www.scopus.com/inward/record.url?scp=84870417918&partnerID=8YFLogxK
U2 - 10.1007/978-94-007-4584-1-43
DO - 10.1007/978-94-007-4584-1-43
M3 - Conference contribution
C2 - 23080178
AN - SCOPUS:84870417918
SN - 9789400745834
VL - 758
T3 - Advances in Experimental Medicine and Biology
SP - 315
EP - 323
BT - Arterial Chemoreception: From Molecules to Systems
ER -