Effect of chronic caffeine intake on carotid body catecholamine dynamics in control and chronically hypoxic rats

Silvia V. Conde, Ana Obeso, Emília C. Monteiro, Constancio Gonzalez

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Caffeine is the most commonly psychoactive drug, an habitual drink in high altitude sporting, and when acutely taken, it causes profound alterations in carotid body (CB) function and ventilation via adenosine receptors antagonism. In the present work we have investigated the effects of chronic caffeine ingestion in catecholamine (CA) dynamics in the carotid body of control and chronic hypoxic rats. Four groups of animals were used: normoxic (N), caffeine-treated normoxic (1 mg/mL in drinking water 15 days; CafN), chronic hypoxic (CH, 12%O2, 15 days) and chronically hypoxic-caffeine-treated (CafH). Caffeine intake in controls rats did not modify CA content, synthesizing, and releasing responses, and the expression of tyrosine hydroxylase. CH increased dopamine content, synthesis, and basal and acute hypoxia-induced release; chronic caffeine ingestion augmented CH effects. Findings indicate that chronic caffeine ingestion in normoxic rats did not modify dopamine dynamics at the CB, but increases dopaminergic system during chronic hypoxia.

Original languageEnglish
Title of host publicationArterial Chemoreception: From Molecules to Systems
Pages315-323
Number of pages9
Volume758
DOIs
Publication statusPublished - 2012

Publication series

NameAdvances in Experimental Medicine and Biology
Volume758
ISSN (Print)00652598

Keywords

  • Caffeine
  • Carotid body
  • Catecholamines
  • Chronic hypoxia

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    Conde, S. V., Obeso, A., Monteiro, E. C., & Gonzalez, C. (2012). Effect of chronic caffeine intake on carotid body catecholamine dynamics in control and chronically hypoxic rats. In Arterial Chemoreception: From Molecules to Systems (Vol. 758, pp. 315-323). (Advances in Experimental Medicine and Biology; Vol. 758). https://doi.org/10.1007/978-94-007-4584-1-43