Early transcriptional response to chloroquine of the Plasmodium falciparum antioxidant defence in sensitive and resistant clones

Maria de Fátima Carvalho Nogueira, A Diez , A Radfar, S Pérez-Benavente, Virgilio Estólio do Rosário, A Puyet , JM Bautista

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24 Citations (Scopus)

Abstract

Resistance to chloroquine (CQ) in Plasmodium falciparum has a major impact on malaria control worldwide To gain insight into early parasite stress response, mRNA expression profiles were determined for a set of 10 antioxidant defence genes in synchronized CQ-sensitive (307) and CQ-resistant (Dd2) clones under transient 1050 CQ-exposure (Dd2, 200 nM; 307, 14 nM) Upon 2-h CQ challenge, the mRNA upregulation detected was greater in 3D7 (six genes overexpressed at 1/3 of the intraerythrocytic cycle) than in Dd2 clone (three genes responding), providing evidence of an early transcriptional response to CQ-induced oxidative stress which might underlie some of the parasite's metabolic adaptation to the drug (c) 2010 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)109-115
JournalActa Tropica
Volume114
Issue number2
DOIs
Publication statusPublished - 1 Jan 2010

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