Dyspepsia treatment with Al compounds widely used in clinical practice - An animal model approach

T. Pinheiro; J. Canena; J. Reis; A. M. Santos; A. S. Pinto; M. G. Quina; M. A. Reis; L. C. Alves

doi:10.1016/0168-583X(95)00928-0

Dyspepsia treatment with Al compounds widely used in clinical practice - An animal model approach

T. Pinheiro, J. Canena, J. Reis, A. M. Santos, A. S. Pinto, M. G. Quina, M. A. Reis, L. C. Alves

NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

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2 Citations (Scopus)

Abstract

The potential toxic effects of Al to organs and tissues used in drugs commonly applied in dyspepsia as therapeutic, have been studied. Brain, liver, kidney and serum samples obtained from Wistar rats treated with two commercial Alcomplexes were studied and compared with equivalent samples collected from healthy animals receiving a placebo. The major alterations found, connected with the persistent intake of medicaments based on Al compounds, are relative to the accumulation of Al in liver and kidney. Also, the Al levels increase in brain and serum of rats supplemented with one of the Al complexes used. In the liver and kidney samples analyzed alterations in the Cu and Zn content levels were observed. Furthermore, a tendency to the decrease of Fe content in kidney and an increase of the Mn levels in brain is observed. The elemental alterations found are probably related to the intake of the drugs tested and are dependent on the type of the Al complex administered. The results obtained suggest that the long term use of these medicaments in the clinical practice should be thought over.

Original language	English
Pages (from-to)	318-322
Number of pages	5
Journal	Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
Volume	109-110
DOIs	https://doi.org/10.1016/0168-583X(95)00928-0
Publication status	Published - 1996

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Pinheiro, T., Canena, J., Reis, J., Santos, A. M., Pinto, A. S., Quina, M. G., Reis, M. A., & Alves, L. C. (1996). Dyspepsia treatment with Al compounds widely used in clinical practice - An animal model approach. Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, 109-110, 318-322. https://doi.org/10.1016/0168-583X(95)00928-0

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title = "Dyspepsia treatment with Al compounds widely used in clinical practice - An animal model approach",

abstract = "The potential toxic effects of Al to organs and tissues used in drugs commonly applied in dyspepsia as therapeutic, have been studied. Brain, liver, kidney and serum samples obtained from Wistar rats treated with two commercial Alcomplexes were studied and compared with equivalent samples collected from healthy animals receiving a placebo. The major alterations found, connected with the persistent intake of medicaments based on Al compounds, are relative to the accumulation of Al in liver and kidney. Also, the Al levels increase in brain and serum of rats supplemented with one of the Al complexes used. In the liver and kidney samples analyzed alterations in the Cu and Zn content levels were observed. Furthermore, a tendency to the decrease of Fe content in kidney and an increase of the Mn levels in brain is observed. The elemental alterations found are probably related to the intake of the drugs tested and are dependent on the type of the Al complex administered. The results obtained suggest that the long term use of these medicaments in the clinical practice should be thought over.",

author = "T. Pinheiro and J. Canena and J. Reis and Santos, {A. M.} and Pinto, {A. S.} and Quina, {M. G.} and Reis, {M. A.} and Alves, {L. C.}",

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Pinheiro, T, Canena, J , Reis, J , Santos, AM , Pinto, AS, Quina, MG, Reis, MA & Alves, LC 1996, 'Dyspepsia treatment with Al compounds widely used in clinical practice - An animal model approach', Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, vol. 109-110, pp. 318-322. https://doi.org/10.1016/0168-583X(95)00928-0

Dyspepsia treatment with Al compounds widely used in clinical practice - An animal model approach. / Pinheiro, T.; Canena, J.; Reis, J.; Santos, A. M.; Pinto, A. S.; Quina, M. G.; Reis, M. A.; Alves, L. C.

In: Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, Vol. 109-110, 1996, p. 318-322.

Research output: Contribution to journal › Article

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T1 - Dyspepsia treatment with Al compounds widely used in clinical practice - An animal model approach

AU - Pinheiro, T.

AU - Canena, J.

AU - Reis, J.

AU - Santos, A. M.

AU - Pinto, A. S.

AU - Quina, M. G.

AU - Reis, M. A.

AU - Alves, L. C.

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AB - The potential toxic effects of Al to organs and tissues used in drugs commonly applied in dyspepsia as therapeutic, have been studied. Brain, liver, kidney and serum samples obtained from Wistar rats treated with two commercial Alcomplexes were studied and compared with equivalent samples collected from healthy animals receiving a placebo. The major alterations found, connected with the persistent intake of medicaments based on Al compounds, are relative to the accumulation of Al in liver and kidney. Also, the Al levels increase in brain and serum of rats supplemented with one of the Al complexes used. In the liver and kidney samples analyzed alterations in the Cu and Zn content levels were observed. Furthermore, a tendency to the decrease of Fe content in kidney and an increase of the Mn levels in brain is observed. The elemental alterations found are probably related to the intake of the drugs tested and are dependent on the type of the Al complex administered. The results obtained suggest that the long term use of these medicaments in the clinical practice should be thought over.

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