Drug-induced accelerated nodulosis: review of the literature

Ana G. Palmeiro, Maria H. Lourenço, Alexandre Miroux-Catarino, Inês Crispim, Jaime C. Branco, Isabel Viana

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


Accelerated nodulosis, the rapid progression/extension of preexisting nodules, is a recognized complication of immunomodulatory therapy, occurring mostly in patients with rheumatoid arthritis treated with methotrexate. As of today, its physiopathology remains incompletely understood, and there are no standardized guidelines regarding its management. Here, we conduct a literature review of the reported cases of drug-induced accelerated nodulosis and add our case of a 79-year-old female with an atypical clinical presentation.

Original languageEnglish
Pages (from-to)432-440
JournalInternational Journal of Dermatology
Issue number3
Early online date2022
Publication statusPublished - Mar 2023


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