Drug-Derived Surface-Active Ionic Liquids: A Cost-Effective Way To Expressively Increase the Blood-Stage Antimalarial Activity of Primaquine

Ana Teresa Silva, Isabel S. Oliveira, Joana Gomes, Luísa Aguiar, Diana Fontinha, Denise Duarte, Fátima Nogueira, Miguel Prudêncio, Eduardo F. Marques, Cátia Teixeira, Ricardo Ferraz, Paula Gomes

Research output: Contribution to journalArticlepeer-review

Abstract

Inspired by previous disclosure of room-temperature ionic liquids derived from primaquine and cinnamic acids, which displayed slightly enhanced blood-stage activity compared to the parent drug, we have now combined this emblematic antimalarial with natural fatty acids. This affords surface-active ionic liquids whose liver-stage antiplasmodial activity is either retained or slightly enhanced, while revealing blood-stage antiplasmodial activity at least one order of magnitude higher than that of the parent compound. These findings open new perspectives towards the cost-effective recycling of classical drugs that are either shelved or in decline, and which is not limited to antimalarial agents.

Original languageEnglish
Article numbere202100650
Pages (from-to)1-6
Number of pages6
JournalChemmedchem
Early online date23 Dec 2021
DOIs
Publication statusE-pub ahead of print - 23 Dec 2021

Keywords

  • Antimalarial
  • blood-stage
  • fatty acid
  • ionic liquid
  • liver-stage
  • Plasmodium
  • SAIL
  • surface activity

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