Drug Delivery by Controlling a Supramolecular Host–Guest Assembly with a Reversible Photoswitch

Nuno Basílio, Uwe Pischel

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

The reversibly switchable trans-chalcone/flavylium photochromic system was successfully coupled to the complexation equilibrium of a drug-cucurbit[7]uril host–guest assembly. Hence, the phototriggered release of memantine under illumination at 366 nm was observed. The process can be partially reverted through a thermally activated back reaction.

Original languageEnglish
Pages (from-to)15208-15211
Number of pages4
JournalChemistry-A European Journal
Volume22
Issue number43
DOIs
Publication statusPublished - 17 Oct 2016

Keywords

  • cucurbiturils
  • drug delivery
  • flavylium
  • host–guest chemistry
  • photochemistry

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