@article{1d8923df017f4b7c82c2fadd8e0d007b,
title = "Do GnRH Agonists Really Increase Body Weight Gain? Evaluation of a Multicentric Portuguese Cohort of Patients With Central Precocious Puberty",
abstract = "Introduction: There are several concerns associated with gonadotropin-releasing hormone agonist (GnRHa) treatment for central precocious puberty (CPP), such as obesity and changes in body mass index (BMI). We aimed to investigate whether any anthropometric differences exist and if they persist over time. Methods: We conducted an observational study of Portuguese children (both sexes) diagnosed with CPP between January 2000 and December 2017, using a digital platform, in order to analyze the influence of GnRHa treatment on BMI-SD score (BMI-SDS). Results: Of the 241 patients diagnosed with CPP, we assessed 92 patients (8% boys) in this study. At baseline, 39% of the patients were overweight. BMI-SDS increased with treatment for girls but then diminished 1 year after stopping GnRHa therapy (p = 0.018). BMI-SDS variation at the end of treatment was negatively correlated with BMI-SDS at baseline (p < 0.001). Boys grew taller and faster during treatment than did girls (p < 0.001), and therefore, their BMI-SDS trajectory might be different. Conclusions: This study showed an increase of body weight gain during GnRHa treatment only in girls, which reversed just 1 year after stopping treatment. The overall gain in BMI-SDS with treatment is associated with baseline BMI-SDS.",
keywords = "body mass index (BMI), central precocious puberty (CPP), GnRH agonists, obesity, weight gain (WG)",
author = "Leite, {Ana Lu{\'i}sa} and Elisa Galo and Ana Antunes and Br{\'i}gida Robalo and Daniela Amaral and Filipa Espada and Sofia Castro and {Sim{\~o}es Dias}, Sara and Catarina Limbert",
note = "Funding Information: We would like to thank all the colleagues who collected data for the National Database: Joana Serra, Unidade de Endocrinologia Pedi{\'a}trica, Hospital Pedi{\'a}trico de Coimbra, Portugal; Marcelo Fonseca, Unidade de Endocrinologia Pedi{\'a}trica, Hospital Pedro Hispano, Matosinhos, Portugal; Maria Jo{\~a}o Oliveira, Unidade de Endocrinologia Pedi{\'a}trica, Centro Materno Infantil do Norte, Porto, Portugal; Maria Miguel Gomes, Unidade de Endocrinologia Pedi{\'a}trica, Hospital de Braga, Portugal; Paula Vieira, Servi{\c c}o de Pediatria, Hospital S{\~a}o Francisco Xavier, Lisbon, Portugal; Rita Silva, Unidade de Endocrinologia Pedi{\'a}trica, Hospital de S{\~a}o Jo{\~a}o, Porto, Portugal; S{\'o}nia Gomes, Unidade de Endocrinologia Pedi{\'a}trica, Centro Hospitalar Universit{\'a}rio de Lisboa Central, Lisbon, Portugal; Susana Figueiredo, Servi{\c c}o de Pediatria, Hospital de Viana de Castelo, Portugal; and Susana Pacheco, Unidade de Endocrinologia Pedi{\'a}trica, Hospital Fernando da Fonseca, Amadora, Portugal. We also thank all children, adolescents, and their parents for their cooperation and understanding. This investigator-initiated study was supported by an unconditional research grant from Ipsen. Funding Information: We would like to thank all the colleagues who collected data for the National Database: Joana Serra, Unidade de Endocrinologia Pedi?trica, Hospital Pedi?trico de Coimbra, Portugal; Marcelo Fonseca, Unidade de Endocrinologia Pedi?trica, Hospital Pedro Hispano, Matosinhos, Portugal; Maria Jo?o Oliveira, Unidade de Endocrinologia Pedi?trica, Centro Materno Infantil do Norte, Porto, Portugal; Maria Miguel Gomes, Unidade de Endocrinologia Pedi?trica, Hospital de Braga, Portugal; Paula Vieira, Servi?o de Pediatria, Hospital S?o Francisco Xavier, Lisbon, Portugal; Rita Silva, Unidade de Endocrinologia Pedi?trica, Hospital de S?o Jo?o, Porto, Portugal; S?nia Gomes, Unidade de Endocrinologia Pedi?trica, Centro Hospitalar Universit?rio de Lisboa Central, Lisbon, Portugal; Susana Figueiredo, Servi?o de Pediatria, Hospital de Viana de Castelo, Portugal; and Susana Pacheco, Unidade de Endocrinologia Pedi?trica, Hospital Fernando da Fonseca, Amadora, Portugal. We also thank all children, adolescents, and their parents for their cooperation and understanding. This investigator-initiated study was supported by an unconditional research grant from Ipsen. Publisher Copyright: Copyright {\textcopyright} 2022 Leite, Galo, Antunes, Robalo, Amaral, Espada, Castro, Sim{\~o}es Dias and Limbert.",
year = "2022",
month = mar,
day = "4",
doi = "10.3389/fped.2022.816635",
language = "English",
volume = "10",
journal = "Frontiers in Pediatrics",
issn = "2296-2360",
publisher = "Frontiers Media",
}
