Abstract
DNA strand breaks and chromosomal aberrations (CAs) were studied in human cells treated with hydrogen peroxide or with ionizing radiation. DNA strand breaks could be produced at dose levels of H2O2 much lower than those which induced CAs. Doses as low as 0.5 mM of H2O2 produced about as many DNA strand breaks as 2 Gy of 60Co gamma-radiation. On the other hand, as much as 20 mM H2O2 produced only half as many CAs as 1 Gy of 60Co gamma-radiation. The different mechanisms involved in the production of human genetic damage by H2O2 and gamma-radiation are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 197-204 |
| Number of pages | 8 |
| Journal | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis |
| Volume | 289 |
| Issue number | 2 |
| Publication status | Published - Oct 1993 |
Keywords
- Adult
- Cells, Cultured
- Chromosome Aberrations
- Cobalt Radioisotopes
- DNA
- DNA Damage
- Gamma Rays
- Humans
- Hydrogen Peroxide
- Leukocytes
- Middle Aged
- Journal Article
- Research Support, Non-U.S. Gov't
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Cite this
Rueff, J., Brás, A., Cristóvão, L., Mexia, J., Sá da Costa, M., & Pires, V. (1993). DNA strand breaks and chromosomal aberrations induced by H2O2 and 60Co gamma-radiation. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 289(2), 197-204.