DNA strand breaks and chromosomal aberrations induced by H2O2 and 60Co gamma-radiation

J. Rueff, A. Brás, L Cristóvão, J Mexia, M Sá da Costa, V Pires

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

DNA strand breaks and chromosomal aberrations (CAs) were studied in human cells treated with hydrogen peroxide or with ionizing radiation. DNA strand breaks could be produced at dose levels of H2O2 much lower than those which induced CAs. Doses as low as 0.5 mM of H2O2 produced about as many DNA strand breaks as 2 Gy of 60Co gamma-radiation. On the other hand, as much as 20 mM H2O2 produced only half as many CAs as 1 Gy of 60Co gamma-radiation. The different mechanisms involved in the production of human genetic damage by H2O2 and gamma-radiation are discussed.

Original languageEnglish
Pages (from-to)197-204
Number of pages8
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume289
Issue number2
Publication statusPublished - Oct 1993

Keywords

  • Adult
  • Cells, Cultured
  • Chromosome Aberrations
  • Cobalt Radioisotopes
  • DNA
  • DNA Damage
  • Gamma Rays
  • Humans
  • Hydrogen Peroxide
  • Leukocytes
  • Middle Aged
  • Journal Article
  • Research Support, Non-U.S. Gov't

Fingerprint Dive into the research topics of 'DNA strand breaks and chromosomal aberrations induced by H2O2 and 60Co gamma-radiation'. Together they form a unique fingerprint.

  • Cite this