Distribution ratios of lipase-catalyzed reaction products in ionic liquid supercritical CO₂ systems: Resolution of 2-octanol enantiomers

This paper presents vapor-liquid equilibrium (VLE) data for systems containing high-pressure CO₂, an ionic liquid, and products of an enzymatic reaction between succinic anhydride and (R,S)-2-octanol in the presence of a lipase. VLE experiments were used to calculate partition coefficients of reaction products between the ionic liquid-rich phase and the CO₂Vrich phase. Experiments of extraction with CO₂ from an ionic liquid of (S)-2-octanol in conditions similar to those of the postreaction mixture were also carried out. The extraction at 11 MPa and 35 °C allows one to recover completely the unreacted enantiomer of 2-octanol with very high enantiomeric excess (98.42%).