Discovery of Novel Plant Peptides as Strong Inhibitors of Metalloproteinases

Rita Francisco; Cândido Pinto Ricardo

doi:10.2174/092986609788167789

Discovery of Novel Plant Peptides as Strong Inhibitors of Metalloproteinases

Rita Francisco, Cândido Pinto Ricardo

Instituto de Tecnologia Química e Biológica António Xavier (ITQB)

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Five novel metalloproteinase protein inhibitors (MPIs) with molecular mass between 5.6 and 8.9 kDa and acid/neutral pI were detected in lupin seeds and exhibited strong inhibitory activities against thermolysin and/or gelatinase B. These novel peptides constitute not only the first MPIs described in plants but also the first plant peptides with inhibitory activity against a matrixin.

Original language	Unknown
Pages (from-to)	543-551
Journal	Protein And Peptide Letters
Volume	16
Issue number	5
DOIs	https://doi.org/10.2174/092986609788167789
Publication status	Published - 1 Jan 2009

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10.2174/092986609788167789

Cite this

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title = "Discovery of Novel Plant Peptides as Strong Inhibitors of Metalloproteinases",

abstract = "Five novel metalloproteinase protein inhibitors (MPIs) with molecular mass between 5.6 and 8.9 kDa and acid/neutral pI were detected in lupin seeds and exhibited strong inhibitory activities against thermolysin and/or gelatinase B. These novel peptides constitute not only the first MPIs described in plants but also the first plant peptides with inhibitory activity against a matrixin.",

keywords = "MASS-SPECTROMETRY, PSEUDOMONAS-AERUGINOSA, SERRATIA-MARCESCENS, FAMILY, SNAKE-VENOM, LUPINUS-ALBUS, MATRIX METALLOPROTEINASES, PROTEIN INHIBITORS, MATRIX-METALLOPROTEINASE-9, PROTEOLYTIC-ENZYMES",

author = "Rita Francisco and {Pinto Ricardo}, C{\^a}ndido",

note = "Carrilho, Dina M Francisco, Rita Ricardo CPP",

year = "2009",

month = jan,

day = "1",

doi = "10.2174/092986609788167789",

language = "Unknown",

volume = "16",

pages = "543--551",

journal = "Protein And Peptide Letters",

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TY - JOUR

T1 - Discovery of Novel Plant Peptides as Strong Inhibitors of Metalloproteinases

AU - Francisco, Rita

AU - Pinto Ricardo, Cândido

N1 - Carrilho, Dina M Francisco, Rita Ricardo CPP

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Five novel metalloproteinase protein inhibitors (MPIs) with molecular mass between 5.6 and 8.9 kDa and acid/neutral pI were detected in lupin seeds and exhibited strong inhibitory activities against thermolysin and/or gelatinase B. These novel peptides constitute not only the first MPIs described in plants but also the first plant peptides with inhibitory activity against a matrixin.

AB - Five novel metalloproteinase protein inhibitors (MPIs) with molecular mass between 5.6 and 8.9 kDa and acid/neutral pI were detected in lupin seeds and exhibited strong inhibitory activities against thermolysin and/or gelatinase B. These novel peptides constitute not only the first MPIs described in plants but also the first plant peptides with inhibitory activity against a matrixin.

KW - MASS-SPECTROMETRY

KW - PSEUDOMONAS-AERUGINOSA

KW - SERRATIA-MARCESCENS

KW - FAMILY

KW - SNAKE-VENOM

KW - LUPINUS-ALBUS

KW - MATRIX METALLOPROTEINASES

KW - PROTEIN INHIBITORS

KW - MATRIX-METALLOPROTEINASE-9

KW - PROTEOLYTIC-ENZYMES

U2 - 10.2174/092986609788167789

DO - 10.2174/092986609788167789

M3 - Article

SN - 0929-8665

VL - 16

SP - 543

EP - 551

JO - Protein And Peptide Letters

JF - Protein And Peptide Letters

IS - 5

ER -