@article{dc05d474f933435a8f09a5d41e328d15,
title = "Discovery of Novel Fluorescent Azaindoles with Cytotoxic Action in A2780 Ovarian Carcinoma Cells",
abstract = "Azaindole scaffold is a privileged structure in medicinal chemistry and some derivatives have demonstrated to be potential anticancer drugs. Herein, a set of novel azaindoles, comprising the four regioisomers, bearing a morpholine (azaindoles 3a-d) and N-methyl-N-benzylamine (azaindoles 4a-d) groups were prepared. Among these compounds, azaindoles 4 exhibited higher cytotoxicity against the ovarian cancer cell line A2780 and normal dermal fibroblasts compared to azaindoles 3. Furthermore, azaindoles 4b and 4c promoted a delay in the cell cycle of the cancer cell line, inspiring an investigation into the intracellular localization of these derivatives.",
keywords = "Anticancer, Antiproliferative, Azaindole, Cell cycle arrest, Citotoxicity",
author = "Cunha, {Jos{\'e} C.} and Catarina Roma-Rodrigues and Ferreira, {Joana R. M.} and Baptista, {Pedro V.} and Fernandes, {Alexandra R.} and S. Guieu and Marques, {M. Manuel B.}",
note = "{\textcopyright} 2024 Wiley‐VCH GmbH. The authors thank the Funda{\c c}{\~a}o para a Ci{\^e}ncia e Tecnologia (FCT, projects PTDC/QUI-QOR/0712/2020) and fellowship UI/BD/151272/2021 (J. R. M. F.). The authors also thank the support by the Laborat{\'o}rio Associado para a Qu{\'i}mica Verde (LAQV), which is financed by national funds from FCT/Minist{\'e}rio da Ci{\^e}ncia, Tecnologia e Ensino Superior FCT/MCTES (LA/P/0008/2020 DOI 10.54499/LA/P/0008/2020, UIDP/50006/2020 DOI 10.54499/UIDP/50006/2020 and UIDB/50006/2020 DOI 10.54499/UIDB/50006/2020), and the CICE-CO-Aveiro Institute of Materials (UID/CTM/50011/2019, UIDB/50011/2020 & UIDP/50011/2020). The National NMR Facility is supported by FCT, ROTEIRO/0031/2013–PINFRA/22161/2016, co-financed by FEDER through COMPETE 2020, POCI, and PORL and FCT through PID-DAC) and CERMAX (022162). This research was funded by the University of Aveiro, FCT/MEC Centro 2020 and Portugal2020, and the COMPETE program.This work is financed by national funds from FCT – Funda{\c c}{\~a}o para a Ci{\^e}ncia e a Tecnologia, I.P., in the scope of the project UIDP/04378/2020 (10.54499/UIDP/04378/2020) and UIDB/04378/2020 (10.54499/UIDB/04378/2020) of the Research Unit on Applied Molecular Biosciences – UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy – i4HB. C.R.-R. was funded by FCT/MCTES, grant number SFRH/BPD/124612/2016",
year = "2024",
month = oct,
day = "16",
doi = "10.1002/cmdc.202400225",
language = "English",
volume = "19",
journal = "Chemmedchem",
issn = "1860-7179",
publisher = "John Wiley & Sons, Ltd.",
number = "20",
}