TY - JOUR
T1 - Differential Urinary Proteomics and Absolute Protein Quantification Reveal Biomarkers of Muscle-Invasive and Non-Muscle-Invasive Bladder Cancer
AU - Montes, João M. R. A.
AU - Carvalho, Luís B.
AU - Domingos, Inês F.
AU - Figueiredo, André Q.
AU - Lodeiro, Carlos
AU - Medeiros, Mariana
AU - Pinheiro, Luís Campos
AU - Capelo, José Luis
AU - Santos, Hugo Miguel
N1 - info:eu-repo/grantAgreement/FCT/Concurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)/LA%2FP%2F0008%2F2020/PT#
info:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Programático/UIDP%2F50006%2F2020/PT#
info:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Base/UIDB%2F50006%2F2020/PT#
info:eu-repo/grantAgreement/FCT/Concurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)/LA%2FP%2F0008%2F2020/PT#
info:eu-repo/grantAgreement/FCT//2023.00528.BD/PT#
Funding Information:
PROTEOMASS Scientific Society is acknowledged by the funding provided to the Laboratory for Biological Mass Spectrometry Isabel Moura (#PM001/2024, #PM001/2019 and #PM003/2016). This work received support from Fundação para a Ciência e a Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior (FCT/MCTES) through the projects LA/P/0008/2020 DOI 10.54499/LA/P/0008/2020, UIDP/50006/2020 DOI 10.54499/UIDP/50006/2020 and UIDB/50006/2020 DOI 10.54499/UIDB/50006/2020. HMS acknowledges the Associate Laboratory for Green Chemistry – LAQV (LA/P/0008/2020) DOI 10.54499/LA/P/0008/2020 funded by FCT/MCTES for his research contract. AQF thanks FCT/MCTES for his PhD grant reference 2023.00528.BD. IFD thanks FCT/MCTES for his PhD grant reference 2024.00745.BD.
Publisher Copyright:
© 2025, Proteomass Scientific Society. All rights reserved.
PY - 2025/4/14
Y1 - 2025/4/14
N2 - A comparative urinary proteomic analysis using the Total Protein Approach (TPA) revealed distinct protein abundance profiles between patients with muscle-invasive (MIBC) and non-muscle-invasive bladder cancer (NMIBC), suggesting potential diagnostic utility. Notably, several proteins, including periostin (POSTN), immunoglobulin variable regions (IGLV3-21, IGHV3-49, IGHV5-51), and complement regulator (C4BPB), were found at significantly higher concentrations in the urine of MIBC patients. These findings support their value as non-invasive indicators of tumour aggressiveness. The TPA-based urinary protein signature holds promise for improving early risk stratification, detecting biological features associated with invasive disease, and may inform treatment strategies.
AB - A comparative urinary proteomic analysis using the Total Protein Approach (TPA) revealed distinct protein abundance profiles between patients with muscle-invasive (MIBC) and non-muscle-invasive bladder cancer (NMIBC), suggesting potential diagnostic utility. Notably, several proteins, including periostin (POSTN), immunoglobulin variable regions (IGLV3-21, IGHV3-49, IGHV5-51), and complement regulator (C4BPB), were found at significantly higher concentrations in the urine of MIBC patients. These findings support their value as non-invasive indicators of tumour aggressiveness. The TPA-based urinary protein signature holds promise for improving early risk stratification, detecting biological features associated with invasive disease, and may inform treatment strategies.
KW - Bladder cancer
KW - Classification
KW - Diagnostic
KW - Proteomics
KW - Total protein approach
KW - TPA
UR - https://www.scopus.com/pages/publications/105003849085
U2 - 10.5584/jiomics.v15i1.245
DO - 10.5584/jiomics.v15i1.245
M3 - Article
AN - SCOPUS:105003849085
SN - 2182-0287
VL - 15
SP - 5
EP - 1
JO - Journal of Integrated OMICS
JF - Journal of Integrated OMICS
IS - 1
M1 - 245
ER -
SDG 3 Good Health and Well-being