TY - JOUR
T1 - Differential behavioural responses to venlafaxine exposure route, warming and acidification in juvenile fish (Argyrosomus regius)
AU - Maulvault, Ana Luísa
AU - Santos, Lúcia H. M. L. M.
AU - Paula, José Ricardo
AU - Camacho, Carolina
AU - Pissarra, Vasco
AU - Fogaça, Fabiola
AU - Barbosa, Vera
AU - Alves, Ricardo
AU - Ferreira, Pedro Pousão
AU - Barceló, Damià
AU - Rodriguez-Mozaz, Sara
AU - Marques, António
AU - Diniz, Mário
AU - Rosa, Rui
N1 - Sem PDF conforme despacho.
info:eu-repo/grantAgreement/EC/FP7/311820/EU#
info:eu-repo/grantAgreement/FCT/5876/147321/PT#
The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under the ECsafeSEAFOOD project (grant agreement no 311820). Sparos Lda company for providing the experimental feeds. The teams from IPMA aquaculture pilot station and LMG for the technical support. The Portuguese Foundation for Science and Technology supported the contract of AM and RR in the framework of the IF program, as well as the PhD Grants of ALM (SFRH/BD/103569/2014) and JRP (SFRH/BD/111153/2015). FCT also supported this work through the strategic project UID/MAR/04292/2013 granted to MARE. L.H.M.L.S. acknowledges the Juan de la Cierva program (FJCI-2014-22377) and S.R.-M. acknowledges the Ramon y Cajal program (RYC-2014-16707).
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Antidepressants, such as venlafaxine (VFX), which are considered emerging environmental pollutants, are increasingly more present in the marine environment, and recent evidence suggest that they might have adverse effects on fish behaviour. Furthermore, altered environmental conditions associated to climate change (e.g. warming and acidification) can also have a determinant role on fish behaviour, fitness and survival. Yet, the underlying interactions between these environmental stressors (pharmaceuticals exposure and climate change) are still far from being fully understood. The aim of this study was to assess behavioural responses (in juvenile meagre (Argyrosomus regius) exposed to VFX via water ([VFX] ~20 μg L−1) and via dietary sources ([VFX] ~160 μg kg−1 dry weight), as well as to increased temperature (ΔT°C = +5 °C) and high CO2 levels (ΔpCO2 ~1000 μatm; equivalent to ΔpH = −0.4 units). Overall, VFX bioaccumulation in fish plasma was enhanced under the combination of warming and acidification. VFX triggered fish exploration, whereas fish activity and shoal cohesion were reduced. Acidification alone decreased fish exploration and shoal cohesion, and reversed fish preference to turn leftwards compared to control conditions. Such alterations were further enhanced by VFX exposure. The combination of warming and acidification also reduced shoal cohesion and loss of lateralization, regardless of VFX exposure. The distinct behaviour observed when VFX contamination, acidification and warming acted alone or in combination highlighted the need to consider the likely interactive effects of seawater warming and acidification in future research regarding the toxicological aspects of chemical contaminants.
AB - Antidepressants, such as venlafaxine (VFX), which are considered emerging environmental pollutants, are increasingly more present in the marine environment, and recent evidence suggest that they might have adverse effects on fish behaviour. Furthermore, altered environmental conditions associated to climate change (e.g. warming and acidification) can also have a determinant role on fish behaviour, fitness and survival. Yet, the underlying interactions between these environmental stressors (pharmaceuticals exposure and climate change) are still far from being fully understood. The aim of this study was to assess behavioural responses (in juvenile meagre (Argyrosomus regius) exposed to VFX via water ([VFX] ~20 μg L−1) and via dietary sources ([VFX] ~160 μg kg−1 dry weight), as well as to increased temperature (ΔT°C = +5 °C) and high CO2 levels (ΔpCO2 ~1000 μatm; equivalent to ΔpH = −0.4 units). Overall, VFX bioaccumulation in fish plasma was enhanced under the combination of warming and acidification. VFX triggered fish exploration, whereas fish activity and shoal cohesion were reduced. Acidification alone decreased fish exploration and shoal cohesion, and reversed fish preference to turn leftwards compared to control conditions. Such alterations were further enhanced by VFX exposure. The combination of warming and acidification also reduced shoal cohesion and loss of lateralization, regardless of VFX exposure. The distinct behaviour observed when VFX contamination, acidification and warming acted alone or in combination highlighted the need to consider the likely interactive effects of seawater warming and acidification in future research regarding the toxicological aspects of chemical contaminants.
KW - Antidepressants
KW - Fish behaviour
KW - Ocean acidification
KW - Ocean warming
KW - Venlafaxine
UR - http://www.scopus.com/inward/record.url?scp=85045286057&partnerID=8YFLogxK
U2 - 10.1016/j.scitotenv.2018.04.015
DO - 10.1016/j.scitotenv.2018.04.015
M3 - Article
C2 - 29660870
AN - SCOPUS:85045286057
VL - 634
SP - 1136
EP - 1147
JO - The Science of the total environment
JF - The Science of the total environment
SN - 0048-9697
ER -