TY - JOUR
T1 - Differences in the genotype frequencies of genes related to blood pressure regulation-a comparative study between South-West Europe and Peri-equatorial Africa
AU - Aguiar, Laura
AU - Semente, Ildegário
AU - Ferreira, Joana
AU - Carvalho, Andreia
AU - Silva, Alda P.
AU - Caroça, Cristina
AU - Caria, Helena
AU - Damasceno, Albertino
AU - Laires, Maria J.
AU - Sardinha, Luís
AU - Monteiro, Cristina
AU - Mascarenhas, Mário R.
AU - Faustino, Paula
AU - Inácio, Ângela
AU - Bicho, Manuel
N1 - Funding Information:
The authors are grateful to all study participants and would like to thank the Instituto de Investiga??o Cient?fica Bento da Rocha Cabral for financial support.
Publisher Copyright:
© 2021 Aguiar L et al.
PY - 2021/12/14
Y1 - 2021/12/14
N2 - Background: Since the emergence of the genus Homo, hominids have occupied a wide variety of environments, facing different selective pressures. Objectives: The aim this study is to compare genotype frequencies between South-West Europe and Peri-equatorial Africa in genes potentially modulators of blood pressure. Methods: The analyzed sample consisted of 325 individuals from Portugal and 226 individuals from Africa (48 from Mozambique and 178 from São Tomé and Príncipe). The following genetic variants were analyzed: intron 4 VNTR in eNOS, rs1050829 in G6PD,-3.7kb α-thalassemic deletion in HBA, rs1800457 in CYB5R3, Hp 1/2 genotype/phenotype in Hp and intron 16 I/D in ACE. Results: Frequencies of genotypes with the 4a allele in eNOS (p<0.001), the G allele in G6PD (p<0.001), the α-3.7 kb in HBA (p <0.001), the C allele in the CYB5R3 (p<0.001) were higher in Peri-equatorial Africa. The Hp 1.1 genotype of Hp has a higher frequency in Peri-equatorial Africa (p=0.002). ACE shows no significant differences. Conclusion: Results show differences in five genetic variants. Conditions of extreme heat and humidity, characteristic of Peri-equatorial Africa, have been associated with increased sodium loss. This study suggests that selected compensatory mechanisms printed in the genome, are nowadays risk factors for hypertension in Peri-equatorial Africa.
AB - Background: Since the emergence of the genus Homo, hominids have occupied a wide variety of environments, facing different selective pressures. Objectives: The aim this study is to compare genotype frequencies between South-West Europe and Peri-equatorial Africa in genes potentially modulators of blood pressure. Methods: The analyzed sample consisted of 325 individuals from Portugal and 226 individuals from Africa (48 from Mozambique and 178 from São Tomé and Príncipe). The following genetic variants were analyzed: intron 4 VNTR in eNOS, rs1050829 in G6PD,-3.7kb α-thalassemic deletion in HBA, rs1800457 in CYB5R3, Hp 1/2 genotype/phenotype in Hp and intron 16 I/D in ACE. Results: Frequencies of genotypes with the 4a allele in eNOS (p<0.001), the G allele in G6PD (p<0.001), the α-3.7 kb in HBA (p <0.001), the C allele in the CYB5R3 (p<0.001) were higher in Peri-equatorial Africa. The Hp 1.1 genotype of Hp has a higher frequency in Peri-equatorial Africa (p=0.002). ACE shows no significant differences. Conclusion: Results show differences in five genetic variants. Conditions of extreme heat and humidity, characteristic of Peri-equatorial Africa, have been associated with increased sodium loss. This study suggests that selected compensatory mechanisms printed in the genome, are nowadays risk factors for hypertension in Peri-equatorial Africa.
KW - Africa
KW - Blood pressure
KW - Genetics
UR - http://www.scopus.com/inward/record.url?scp=85124383261&partnerID=8YFLogxK
U2 - 10.4314/ahs.v21i4.21
DO - 10.4314/ahs.v21i4.21
M3 - Article
C2 - 35283964
AN - SCOPUS:85124383261
SN - 1680-6905
VL - 21
SP - 1669
EP - 1676
JO - African Health Sciences
JF - African Health Sciences
IS - 4
ER -