TY - JOUR
T1 - Dietary selenium intakes and musculoskeletal function in very old adults
T2 - Analysis of the newcastle 85+ study
AU - Perri, Giorgia
AU - Mendonça, Nuno
AU - Jagger, Carol
AU - Walsh, Jennifer
AU - Eastell, Richard
AU - Mathers, John C.
AU - Hill, Tom R.
N1 - Funding: This individual research study received no additional funding. However, we would like to thank The MRC-Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing (CIMA) (https://www. cimauk.org/) for funding the PhD programme of study associated with this research. We would also like to acknowledge the generous donations provided by Cumbria Community Foundation and Beverley Charitable Trust Fund throughout the associated PhD programme of study.
PY - 2020/7
Y1 - 2020/7
N2 - Background: Selenium is a trace element essential for health. Severe selenium deficiencies are associated with poor musculoskeletal (MSK) function. However, the effects of moderate deficiency on MSK function, especially in older adults, is unclear. Objectives: To determine the associations between selenium intake and MSK function in very old adults. Methods: Selenium intake at baseline and, hand-grip strength (HGS) and timed-up-and-go (TUG) at four phases over 5 years, were available in 791 participants in the Newcastle 85+ Study, a community-based, longitudinal cohort of ≥85 year old individuals. We investigated relationships between selenium intake and HGS and TUG in cross-sectional analyses at baseline using multivariate analyses and, prospectively using linear mixed models to explore HGS and TUG changes over 5 years in association with baseline selenium intake. Results: At baseline, 53% of participants had selenium intakes that were classified as low. These individuals had 2.80 kg lower HGS and were 2.30 s slower performing the TUG, cross-sectionally. In multivariate, baseline analyses, selenium intake had no significant impact on HGS or TUG. Selenium intake had no significant effect on MSK function, prospectively. Conclusion: Low selenium intake is common among very old adults and, in cross-sectional analyses, is associated with poorer MSK function.
AB - Background: Selenium is a trace element essential for health. Severe selenium deficiencies are associated with poor musculoskeletal (MSK) function. However, the effects of moderate deficiency on MSK function, especially in older adults, is unclear. Objectives: To determine the associations between selenium intake and MSK function in very old adults. Methods: Selenium intake at baseline and, hand-grip strength (HGS) and timed-up-and-go (TUG) at four phases over 5 years, were available in 791 participants in the Newcastle 85+ Study, a community-based, longitudinal cohort of ≥85 year old individuals. We investigated relationships between selenium intake and HGS and TUG in cross-sectional analyses at baseline using multivariate analyses and, prospectively using linear mixed models to explore HGS and TUG changes over 5 years in association with baseline selenium intake. Results: At baseline, 53% of participants had selenium intakes that were classified as low. These individuals had 2.80 kg lower HGS and were 2.30 s slower performing the TUG, cross-sectionally. In multivariate, baseline analyses, selenium intake had no significant impact on HGS or TUG. Selenium intake had no significant effect on MSK function, prospectively. Conclusion: Low selenium intake is common among very old adults and, in cross-sectional analyses, is associated with poorer MSK function.
KW - Dietary intake
KW - Musculoskeletal function
KW - Newcastle 85+ Study
KW - Selenium
KW - Very old adults
UR - http://www.scopus.com/inward/record.url?scp=85087802231&partnerID=8YFLogxK
U2 - 10.3390/nu12072068
DO - 10.3390/nu12072068
M3 - Article
C2 - 32664662
AN - SCOPUS:85087802231
SN - 1422-8599
VL - 12
SP - 1
EP - 22
JO - Nutrients
JF - Nutrients
IS - 7
M1 - 2068
ER -