Abstract
Increased arterial stiffness is a degenerative vascular process, progressing with age that leads to a reduced capability of arteries to expand and contract in response to pressure changes. This progressive degeneration mainly affects the extracellular matrix of elastic arteries and causes loss of vascular elasticity. Recent studies point to significant interference of dietary polyphenols with mechanisms involved in the pathophysiology and progression of arterial stiffness. This review summarizes data from epidemiological and interventional studies on the effect of polyphenols on vascular stiffness as an illustration of current research and addresses possible etiological factors targeted by polyphenols, including pathways of vascular functionality, oxidative status, inflammation, glycation, and autophagy. Effects can either be inflicted directly by the dietary polyphenols or indirectly by metabolites originated from the host or microbial metabolic processes. The composition of the gut microbiome, therefore, determines the resulting metabolome and, as a consequence, the observed activity. On the other hand, polyphenols also influence the intestinal microbial composition, and therefore the metabolites available for interaction with relevant targets. As such, targeting the gut microbiome is another potential treatment option for arterial stiffness.
| Original language | English |
|---|---|
| Journal | Nutrients |
| Volume | 11 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 8 Mar 2019 |
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Keywords
- aging
- anti-inflammatory
- antioxidant
- arterial stiffness
- autophagy
- gut microbiome
- polyphenol biotransformation
- polyphenols
Cite this
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Dietary Polyphenols Targeting Arterial Stiffness : Interplay of Contributing Mechanisms and Gut Microbiome-Related Metabolism. / De Bruyne, Tess; Steenput, Bieke; Roth, Lynn; De Meyer, Guido R.Y.; Santos, Claudia Nunes Dos; Valentová, Kateřina; Dambrova, Maija; Hermans, Nina.
In: Nutrients, Vol. 11, No. 3, 08.03.2019.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Dietary Polyphenols Targeting Arterial Stiffness
T2 - Interplay of Contributing Mechanisms and Gut Microbiome-Related Metabolism
AU - De Bruyne, Tess
AU - Steenput, Bieke
AU - Roth, Lynn
AU - De Meyer, Guido R.Y.
AU - Santos, Claudia Nunes Dos
AU - Valentová, Kateřina
AU - Dambrova, Maija
AU - Hermans, Nina
PY - 2019/3/8
Y1 - 2019/3/8
N2 - Increased arterial stiffness is a degenerative vascular process, progressing with age that leads to a reduced capability of arteries to expand and contract in response to pressure changes. This progressive degeneration mainly affects the extracellular matrix of elastic arteries and causes loss of vascular elasticity. Recent studies point to significant interference of dietary polyphenols with mechanisms involved in the pathophysiology and progression of arterial stiffness. This review summarizes data from epidemiological and interventional studies on the effect of polyphenols on vascular stiffness as an illustration of current research and addresses possible etiological factors targeted by polyphenols, including pathways of vascular functionality, oxidative status, inflammation, glycation, and autophagy. Effects can either be inflicted directly by the dietary polyphenols or indirectly by metabolites originated from the host or microbial metabolic processes. The composition of the gut microbiome, therefore, determines the resulting metabolome and, as a consequence, the observed activity. On the other hand, polyphenols also influence the intestinal microbial composition, and therefore the metabolites available for interaction with relevant targets. As such, targeting the gut microbiome is another potential treatment option for arterial stiffness.
AB - Increased arterial stiffness is a degenerative vascular process, progressing with age that leads to a reduced capability of arteries to expand and contract in response to pressure changes. This progressive degeneration mainly affects the extracellular matrix of elastic arteries and causes loss of vascular elasticity. Recent studies point to significant interference of dietary polyphenols with mechanisms involved in the pathophysiology and progression of arterial stiffness. This review summarizes data from epidemiological and interventional studies on the effect of polyphenols on vascular stiffness as an illustration of current research and addresses possible etiological factors targeted by polyphenols, including pathways of vascular functionality, oxidative status, inflammation, glycation, and autophagy. Effects can either be inflicted directly by the dietary polyphenols or indirectly by metabolites originated from the host or microbial metabolic processes. The composition of the gut microbiome, therefore, determines the resulting metabolome and, as a consequence, the observed activity. On the other hand, polyphenols also influence the intestinal microbial composition, and therefore the metabolites available for interaction with relevant targets. As such, targeting the gut microbiome is another potential treatment option for arterial stiffness.
KW - aging
KW - anti-inflammatory
KW - antioxidant
KW - arterial stiffness
KW - autophagy
KW - gut microbiome
KW - polyphenol biotransformation
KW - polyphenols
UR - http://www.scopus.com/inward/record.url?scp=85062854208&partnerID=8YFLogxK
U2 - 10.3390/nu11030578
DO - 10.3390/nu11030578
M3 - Review article
VL - 11
JO - Nutrients
JF - Nutrients
SN - 1422-8599
IS - 3
ER -