Dextran nanoparticles: Preparation and applications

Shareefraza J. Ukkund, Bhavna Alke, Syed N. Taqui, Usman T. Syed

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Dextran nanoparticles are grabbing world-wide attention of scientists and technologists for their wide-ranging applications as biomaterials. Dextran, a type of α-glucan is the first commercialized bacterial exopolysaccharide that exhibits high biocompatibility and biodegradability features enabling a large array of applications. This chapter concisely compiles the chemical and enzymatic methods of synthesis, characteristics and myriad applications of dextran-based nanoparticles such as nanocarriers, bioimaging, drug delivery, nanobiosensors, and nanoscaffolds to mention a few. A comprehensive understanding of other dextran-based conjugates, derivatives, hydrogels and micelles being used as nanomedicine is also presented. Although literature reveals sporadic distribution of cytotoxicity studies of dextran-based nanoparticles, a detailed review is accounted for future scope of study. The chapter concludes with an emphasis on the paradigm shift in exploiting dextran for trending applications in nanobiotechnology.

Original languageEnglish
Title of host publicationPolysaccharide Nanoparticles
Subtitle of host publicationPreparation and Biomedical Applications
EditorsJayachandran Venkatesan, Se-Kwon Kim, Sukumaran Anil, Rekha P. D
PublisherElsevier
Chapter1
Pages1-31
Number of pages31
ISBN (Electronic)978-0-12-822356-7
ISBN (Print)978-0-12-822351-2
DOIs
Publication statusPublished - 11 Jan 2022

Publication series

NameMicro and Nano Technologies

Keywords

  • Biomaterial
  • Cytotoxicity
  • Dextran
  • Nanomedicine
  • Nanoparticles
  • Synthesis

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