Developments towards regioselective synthesis of 1,2-disubstituted benzimidazoles

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100 Citations (Scopus)

Abstract

1,2-Disubstituted benzimidazoles play an important role in several areas and particularly as drug discovery targets. Herein, several methods to assemble these structures are reviewed, from the classical approaches to the more recently developed metal-catalyzed intramolecular amination process, the cascade arylamination/condensation reaction and polymer-supported benzimidazole assembly under microwave conditions. From classical to modern: 1,2-Disubstituted benzimidazoles play an important role in several areas and particularly as drug-discovery targets. Several methods to assemble these structures are reviewed, from the classical approaches to the more recently developed processes.

Original languageEnglish
Pages (from-to)12544-12555
Number of pages12
JournalChemistry - A European Journal
Volume17
Issue number45
DOIs
Publication statusPublished - 4 Nov 2011

Keywords

  • amination
  • cross-coupling
  • nitrogen heterocycles
  • regioselectivity
  • synthetic methods

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