TY - JOUR
T1 - Developments towards regioselective synthesis of 1,2-disubstituted benzimidazoles
AU - Carvalho, Luísa C. R.
AU - Fernandes, Eduarda
AU - Marques, M. Manuel B.
N1 - The author acknowledges Fundacao para a Ciencia e Tecnologia for the Ph.D. grant SFRH/BD/63407/2009, and for the project PTDC/QUI/65187/2006.
PY - 2011/11/4
Y1 - 2011/11/4
N2 - 1,2-Disubstituted benzimidazoles play an important role in several areas and particularly as drug discovery targets. Herein, several methods to assemble these structures are reviewed, from the classical approaches to the more recently developed metal-catalyzed intramolecular amination process, the cascade arylamination/condensation reaction and polymer-supported benzimidazole assembly under microwave conditions. From classical to modern: 1,2-Disubstituted benzimidazoles play an important role in several areas and particularly as drug-discovery targets. Several methods to assemble these structures are reviewed, from the classical approaches to the more recently developed processes.
AB - 1,2-Disubstituted benzimidazoles play an important role in several areas and particularly as drug discovery targets. Herein, several methods to assemble these structures are reviewed, from the classical approaches to the more recently developed metal-catalyzed intramolecular amination process, the cascade arylamination/condensation reaction and polymer-supported benzimidazole assembly under microwave conditions. From classical to modern: 1,2-Disubstituted benzimidazoles play an important role in several areas and particularly as drug-discovery targets. Several methods to assemble these structures are reviewed, from the classical approaches to the more recently developed processes.
KW - amination
KW - cross-coupling
KW - nitrogen heterocycles
KW - regioselectivity
KW - synthetic methods
UR - http://www.scopus.com/inward/record.url?scp=80054902396&partnerID=8YFLogxK
U2 - 10.1002/chem.201101508
DO - 10.1002/chem.201101508
M3 - Review article
C2 - 21989969
AN - SCOPUS:80054902396
SN - 0947-6539
VL - 17
SP - 12544
EP - 12555
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
IS - 45
ER -