Development of switchable "smart" biomaterials using an environmental friendly technology

Telma Barroso; Raquel Viveiros; Eunice Costa; Márcio Temtem; Teresa Casimiro; Ana Aguiar-Ricardo

Development of switchable "smart" biomaterials using an environmental friendly technology

Telma Barroso, Raquel Viveiros, Eunice Costa, Márcio Temtem, Teresa Casimiro, Ana Aguiar-Ricardo

DQ - Departamento de Química

Research output: Contribution to journal › Article › peer-review

Abstract

The possibility of using three dimensional porous networks as microreactors for synthesizing thermoresponsive polymers and hydrogels in a CO₂ environment is an important breakthrough in the strategies to prepare smart films, membranes and porous bulky devices that undergo fast reversible changes in surface properties triggered by external stimuli. In situ synthesis of thermoresponsive polymers namely, poly(N-isopropylacrylamide) (PNIPAAm) and poly (N,N-diethylacrylamide) (PDEAAm) within chitosan (CHT), collagen (CLG) and chitosan-collagen (CHT:CLG) blended scaffolds were performed in order to further impregnate with model drugs. The performance of these switchable release devices was evaluated through the study of drug release kinetics as a function of temperature and pH. The same methodology was successfully applied to produce thermoresponsive polysulfone-based membranes.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Materials Research Society Symposium Proceedings
Publication status	Published - 2010
Event	2009 MRS Fall Meeting - Boston, MA, United States Duration: 30 Nov 2009 → 4 Dec 2009

Cite this

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abstract = "The possibility of using three dimensional porous networks as microreactors for synthesizing thermoresponsive polymers and hydrogels in a CO2 environment is an important breakthrough in the strategies to prepare smart films, membranes and porous bulky devices that undergo fast reversible changes in surface properties triggered by external stimuli. In situ synthesis of thermoresponsive polymers namely, poly(N-isopropylacrylamide) (PNIPAAm) and poly (N,N-diethylacrylamide) (PDEAAm) within chitosan (CHT), collagen (CLG) and chitosan-collagen (CHT:CLG) blended scaffolds were performed in order to further impregnate with model drugs. The performance of these switchable release devices was evaluated through the study of drug release kinetics as a function of temperature and pH. The same methodology was successfully applied to produce thermoresponsive polysulfone-based membranes.",

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T1 - Development of switchable "smart" biomaterials using an environmental friendly technology

AU - Barroso, Telma

AU - Viveiros, Raquel

AU - Costa, Eunice

AU - Temtem, Márcio

AU - Casimiro, Teresa

AU - Aguiar-Ricardo, Ana

PY - 2010

Y1 - 2010

N2 - The possibility of using three dimensional porous networks as microreactors for synthesizing thermoresponsive polymers and hydrogels in a CO2 environment is an important breakthrough in the strategies to prepare smart films, membranes and porous bulky devices that undergo fast reversible changes in surface properties triggered by external stimuli. In situ synthesis of thermoresponsive polymers namely, poly(N-isopropylacrylamide) (PNIPAAm) and poly (N,N-diethylacrylamide) (PDEAAm) within chitosan (CHT), collagen (CLG) and chitosan-collagen (CHT:CLG) blended scaffolds were performed in order to further impregnate with model drugs. The performance of these switchable release devices was evaluated through the study of drug release kinetics as a function of temperature and pH. The same methodology was successfully applied to produce thermoresponsive polysulfone-based membranes.

AB - The possibility of using three dimensional porous networks as microreactors for synthesizing thermoresponsive polymers and hydrogels in a CO2 environment is an important breakthrough in the strategies to prepare smart films, membranes and porous bulky devices that undergo fast reversible changes in surface properties triggered by external stimuli. In situ synthesis of thermoresponsive polymers namely, poly(N-isopropylacrylamide) (PNIPAAm) and poly (N,N-diethylacrylamide) (PDEAAm) within chitosan (CHT), collagen (CLG) and chitosan-collagen (CHT:CLG) blended scaffolds were performed in order to further impregnate with model drugs. The performance of these switchable release devices was evaluated through the study of drug release kinetics as a function of temperature and pH. The same methodology was successfully applied to produce thermoresponsive polysulfone-based membranes.

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JO - Materials Research Society Symposium Proceedings

JF - Materials Research Society Symposium Proceedings

T2 - 2009 MRS Fall Meeting

Y2 - 30 November 2009 through 4 December 2009

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Development of switchable "smart" biomaterials using an environmental friendly technology

Abstract

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