Development of switchable "smart" biomaterials using an environmental friendly technology

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The possibility of using three dimensional porous networks as microreactors for synthesizing thermoresponsive polymers and hydrogels in a CO2 environment is an important breakthrough in the strategies to prepare smart films, membranes and porous bulky devices that undergo fast reversible changes in surface properties triggered by external stimuli. In situ synthesis of thermoresponsive polymers namely, poly(N-isopropylacrylamide) (PNIPAAm) and poly (N,N-diethylacrylamide) (PDEAAm) within chitosan (CHT), collagen (CLG) and chitosan-collagen (CHT:CLG) blended scaffolds were performed in order to further impregnate with model drugs. The performance of these switchable release devices was evaluated through the study of drug release kinetics as a function of temperature and pH. The same methodology was successfully applied to produce thermoresponsive polysulfone-based membranes.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalMaterials Research Society Symposium Proceedings
Publication statusPublished - 2010
Event2009 MRS Fall Meeting - Boston, MA, United States
Duration: 30 Nov 20094 Dec 2009


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