Development of poly-2-ethyl-2-oxazoline coated gold-core silica shell nanorods for cancer chemo-photothermal therapy

André F. Moreira; Carolina F. Rodrigues; Catarina A. Reis; Elisabete C. Costa; Paula Ferreira; Ilídio J. Correia

doi:10.2217/nnm-2018-0179

Development of poly-2-ethyl-2-oxazoline coated gold-core silica shell nanorods for cancer chemo-photothermal therapy

André F. Moreira, Carolina F. Rodrigues, Catarina A. Reis, Elisabete C. Costa, Paula Ferreira, Ilídio J. Correia

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Aim: Develop a new poly-2-ethyl-2-oxazoline (PEOZ)-based coating for doxorubicin-loaded gold-core mesoporous silica shell (AuMSS) nanorods application in cancer chemo-photothermal therapy. Methods: PEOZ functionalized AuMSS nanorods were obtained through the chemical grafting on AuMSS of a PEOZ silane derivative. Results: The PEOZ chemical grafting on the surface of AuMSS nanorods allowed the neutralization of nanodevices' surface charge, from -30 to -15 mV, which improved nanoparticles' biocompatibility, namely by decreasing the blood hemolysis to negligible levels. In vitro antitumoral studies revealed that the combined treatment mediated by the PEOZ-coated AuMSS nanorods result in a synergistic effect, allowing the complete eradication of cervical cancer cells. Conclusion: The application of the PEOZ coating improves the AuMSS nanorods performance as a multifunctional combinatorial therapy for cervical cancer.

Original language	English
Journal	Nanomedicine
Volume	13
Issue number	20
DOIs	https://doi.org/10.2217/nnm-2018-0179
Publication status	Published - 1 Jan 2018

Keywords

cancer
combinatorial therapy
drug-delivery
gold-core silica shell nanorods
photothermal therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/nnm-2018-0179

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title = "Development of poly-2-ethyl-2-oxazoline coated gold-core silica shell nanorods for cancer chemo-photothermal therapy",

abstract = "Aim: Develop a new poly-2-ethyl-2-oxazoline (PEOZ)-based coating for doxorubicin-loaded gold-core mesoporous silica shell (AuMSS) nanorods application in cancer chemo-photothermal therapy. Methods: PEOZ functionalized AuMSS nanorods were obtained through the chemical grafting on AuMSS of a PEOZ silane derivative. Results: The PEOZ chemical grafting on the surface of AuMSS nanorods allowed the neutralization of nanodevices' surface charge, from -30 to -15 mV, which improved nanoparticles' biocompatibility, namely by decreasing the blood hemolysis to negligible levels. In vitro antitumoral studies revealed that the combined treatment mediated by the PEOZ-coated AuMSS nanorods result in a synergistic effect, allowing the complete eradication of cervical cancer cells. Conclusion: The application of the PEOZ coating improves the AuMSS nanorods performance as a multifunctional combinatorial therapy for cervical cancer.",

keywords = "cancer, combinatorial therapy, drug-delivery, gold-core silica shell nanorods, photothermal therapy",

author = "Moreira, {Andr{\'e} F.} and Rodrigues, {Carolina F.} and Reis, {Catarina A.} and Costa, {Elisabete C.} and Paula Ferreira and Correia, {Il{\'i}dio J.}",

note = "This work was supported by FEDER funds through the POCI - COMPETE 2020 - Operational Programme Competitiveness and Internationalisation in Axis I - Strengthening research, technological development and innovation (Project POCI-01-0145-FEDER-007491) and National Funds by FCT - Foundation for Science and Technology (Project UID/Multi/00709/2013). The funding from CENTRO-01-0145-FEDER-028989 and POCI-01-0145-FEDER-031462 are also acknowledged. AF Moreira and EC Costa acknowledge for their individual Ph.D. fellowship from FCT (SFRH/BD/109482/2015 and SFRH/BD/103507/2014, respectively). ",

year = "2018",

month = jan,

day = "1",

doi = "10.2217/nnm-2018-0179",

language = "English",

volume = "13",

journal = "Nanomedicine",

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T1 - Development of poly-2-ethyl-2-oxazoline coated gold-core silica shell nanorods for cancer chemo-photothermal therapy

AU - Moreira, André F.

AU - Rodrigues, Carolina F.

AU - Reis, Catarina A.

AU - Costa, Elisabete C.

AU - Ferreira, Paula

AU - Correia, Ilídio J.

N1 - This work was supported by FEDER funds through the POCI - COMPETE 2020 - Operational Programme Competitiveness and Internationalisation in Axis I - Strengthening research, technological development and innovation (Project POCI-01-0145-FEDER-007491) and National Funds by FCT - Foundation for Science and Technology (Project UID/Multi/00709/2013). The funding from CENTRO-01-0145-FEDER-028989 and POCI-01-0145-FEDER-031462 are also acknowledged. AF Moreira and EC Costa acknowledge for their individual Ph.D. fellowship from FCT (SFRH/BD/109482/2015 and SFRH/BD/103507/2014, respectively).

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Aim: Develop a new poly-2-ethyl-2-oxazoline (PEOZ)-based coating for doxorubicin-loaded gold-core mesoporous silica shell (AuMSS) nanorods application in cancer chemo-photothermal therapy. Methods: PEOZ functionalized AuMSS nanorods were obtained through the chemical grafting on AuMSS of a PEOZ silane derivative. Results: The PEOZ chemical grafting on the surface of AuMSS nanorods allowed the neutralization of nanodevices' surface charge, from -30 to -15 mV, which improved nanoparticles' biocompatibility, namely by decreasing the blood hemolysis to negligible levels. In vitro antitumoral studies revealed that the combined treatment mediated by the PEOZ-coated AuMSS nanorods result in a synergistic effect, allowing the complete eradication of cervical cancer cells. Conclusion: The application of the PEOZ coating improves the AuMSS nanorods performance as a multifunctional combinatorial therapy for cervical cancer.

AB - Aim: Develop a new poly-2-ethyl-2-oxazoline (PEOZ)-based coating for doxorubicin-loaded gold-core mesoporous silica shell (AuMSS) nanorods application in cancer chemo-photothermal therapy. Methods: PEOZ functionalized AuMSS nanorods were obtained through the chemical grafting on AuMSS of a PEOZ silane derivative. Results: The PEOZ chemical grafting on the surface of AuMSS nanorods allowed the neutralization of nanodevices' surface charge, from -30 to -15 mV, which improved nanoparticles' biocompatibility, namely by decreasing the blood hemolysis to negligible levels. In vitro antitumoral studies revealed that the combined treatment mediated by the PEOZ-coated AuMSS nanorods result in a synergistic effect, allowing the complete eradication of cervical cancer cells. Conclusion: The application of the PEOZ coating improves the AuMSS nanorods performance as a multifunctional combinatorial therapy for cervical cancer.

KW - cancer

KW - combinatorial therapy

KW - drug-delivery

KW - gold-core silica shell nanorods

KW - photothermal therapy

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JO - Nanomedicine

JF - Nanomedicine

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Development of poly-2-ethyl-2-oxazoline coated gold-core silica shell nanorods for cancer chemo-photothermal therapy

Abstract

Keywords

UN SDGs

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