Development of multicore hybrid particles for drug delivery through the precipitation of CO2 saturated emulsions

V. S S Gonçalves, S. Rodríguez-Rojo, A. A. Matias, Ana Vital Morgado Marques Nunes, I. D. Nogueira, D. Nunes, E. Fortunato, A. P Alves De Matos, M. J. Cocero, C.M.M. Duarte

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Hybrid lipid-polymer particles are gaining increasing interest to be applied as drug delivery systems due to their greater stability in biological fluids and enhanced cellular uptake of drugs. However, a major drawback is the fact that these particles are usually produced through techniques that use organic solvents. This work studies the possibility of producing for the first time hybrid particles composed by lipid multicores enveloped in a polymeric layer through Particles from Gas Saturated Solutions (PGSS (R)), without using organic solvents. An oil-in-water emulsion, composed by Gelucire 43/01 (TM) (GEL) as the discontinuous phase and by an aqueous polyethylene glycol 4000 (PEG) solution as the continuous phase, was successfully precipitated by PGSS (R). Operating conditions that ensured the stability of the CO2 saturated emulsion were previously evaluated. The resulting PEG-GEL particles present a spherical-like morphology constituted by several lipid cores encapsulated into a polymeric shell. The applicability of these structured particles to be used as drug delivery system (DDS) was studied by using ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), as model drug. The particles provided an initial burst release of the drug due to the progressive dissolution of the external layer of PEG, followed by a controlled release of the NSAID from the GEL cores. (C) 2014 Published by Elsevier B.V.

Original languageEnglish
Pages (from-to)9-18
Number of pages10
JournalInternational Journal of Pharmaceutics
Volume478
Issue number1
DOIs
Publication statusPublished - 15 Jan 2015

Fingerprint

Emulsions
Drug Delivery Systems
Lipids
Pharmaceutical Preparations
Anti-Inflammatory Agents
Gases
Ketoprofen
Polymers
Oils
Water
polyethylene glycol 4000

Keywords

  • Drug delivery systems
  • Emulsion
  • Multicore hybrid particles
  • Particles from Gas Saturated Solutions
  • Supercritical fluids

Cite this

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abstract = "Hybrid lipid-polymer particles are gaining increasing interest to be applied as drug delivery systems due to their greater stability in biological fluids and enhanced cellular uptake of drugs. However, a major drawback is the fact that these particles are usually produced through techniques that use organic solvents. This work studies the possibility of producing for the first time hybrid particles composed by lipid multicores enveloped in a polymeric layer through Particles from Gas Saturated Solutions (PGSS (R)), without using organic solvents. An oil-in-water emulsion, composed by Gelucire 43/01 (TM) (GEL) as the discontinuous phase and by an aqueous polyethylene glycol 4000 (PEG) solution as the continuous phase, was successfully precipitated by PGSS (R). Operating conditions that ensured the stability of the CO2 saturated emulsion were previously evaluated. The resulting PEG-GEL particles present a spherical-like morphology constituted by several lipid cores encapsulated into a polymeric shell. The applicability of these structured particles to be used as drug delivery system (DDS) was studied by using ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), as model drug. The particles provided an initial burst release of the drug due to the progressive dissolution of the external layer of PEG, followed by a controlled release of the NSAID from the GEL cores. (C) 2014 Published by Elsevier B.V.",
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Development of multicore hybrid particles for drug delivery through the precipitation of CO2 saturated emulsions. / Gonçalves, V. S S; Rodríguez-Rojo, S.; Matias, A. A.; Nunes, Ana Vital Morgado Marques; Nogueira, I. D.; Nunes, D.; Fortunato, E.; De Matos, A. P Alves; Cocero, M. J.; Duarte, C.M.M.

In: International Journal of Pharmaceutics, Vol. 478, No. 1, 15.01.2015, p. 9-18.

Research output: Contribution to journalArticle

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AU - Gonçalves, V. S S

AU - Rodríguez-Rojo, S.

AU - Matias, A. A.

AU - Nunes, Ana Vital Morgado Marques

AU - Nogueira, I. D.

AU - Nunes, D.

AU - Fortunato, E.

AU - De Matos, A. P Alves

AU - Cocero, M. J.

AU - Duarte, C.M.M.

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