Abstract
Different Chiral Ionic Liquids (CIL) based on L-proline have been developed. Simple and efficient synthetic methodologies are used, allowing preparation in good yields for twelve novel CILs using L-proline as a cation or anion combined with suitable counter-ions. A detailed physical and chemical characterization of the CILs was performed to evaluate the influence of counter-ions on the final properties. The most promissory CILs were tested as efficient chiral catalysts in IL media for asymmetric Michael addition reactions of ketones and aldehydes to nitro-olefins. Similar or even better conversions and enantioselectivities (ee up to 95%) compared to the original L-proline were achieved. Additionally, a good product extraction performance using supercritical CO2 processes was obtained.
Original language | English |
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Article number | 270 |
Number of pages | 16 |
Journal | Catalysts |
Volume | 13 |
DOIs | |
Publication status | Published - 25 Jan 2023 |
Keywords
- asymmetric Michael reaction
- chiral ionic liquids
- L-proline
- supercritical CO extraction