TY - JOUR
T1 - Development of itaconic acid-based molecular imprinted polymers using supercritical fluid technology for pH-triggered drug delivery
AU - Marcelo, Gonçalo
AU - Ferreira, Inês C.
AU - Viveiros, Raquel
AU - Casimiro, Teresa
N1 - The authors would like to thank financial support from Fundacao para a Ciencia e a Tecnologia, Ministerio da Ciencia, Tecnologia e Ensino Superior (FCT/MCTES), Portugal, through project PTDC/QEQ-PRS/2757/2012 and Principal Investigator-FCT contract IF/00915/2014 (T.C.). The Associate Laboratory Research Unit for Green Chemistry - Clean Technologies and Processes - LAQV-REQUIMTE is financed by national funds from FCT/MCTES (UID/QUI/50006/2013) and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER - 007265).
PY - 2018/5/5
Y1 - 2018/5/5
N2 - A novel pH-responsive molecularly imprinted polymer (MIP) based on Itaconic acid:Ethylene glycol dimethacrylate was developed as a potential body-friendly oral drug delivery system for metronidazole (MZ), a pH-independent drug. MIP performance was evaluated in a simulated oral administration situation, at pHs 2.2 and 7.4. Itaconic acid-based copolymers were synthesized using two different molar ratios of template:monomer:crosslinker (T:M:C), 1:5:25 and 1:5:50, in supercritical carbon dioxide (scCO2) in high yields. Further, impregnation of MZ was performed in scCO2 environment. Morphological and chemical properties of the copolymers produced were assessed by SEM, Morphologi G3 and FTIR analyses. Non-molecularly imprinted polymer (NIP) matrices presented swelling over time in opposition to the molecularly imprinted ones. In the scCO2-impregnation process, MIPs showed a significant molecular recognition towards MZ, presenting higher drug uptake ability with MZ loading of 18-61 wt% in MIPs, compared to 7–20 wt% in NIPs. In vitro drug release experiments presented different release profiles at the different pHs, where MZ-MIPs could release higher amounts of MZ at the lowest pH than at pH 7.4.
AB - A novel pH-responsive molecularly imprinted polymer (MIP) based on Itaconic acid:Ethylene glycol dimethacrylate was developed as a potential body-friendly oral drug delivery system for metronidazole (MZ), a pH-independent drug. MIP performance was evaluated in a simulated oral administration situation, at pHs 2.2 and 7.4. Itaconic acid-based copolymers were synthesized using two different molar ratios of template:monomer:crosslinker (T:M:C), 1:5:25 and 1:5:50, in supercritical carbon dioxide (scCO2) in high yields. Further, impregnation of MZ was performed in scCO2 environment. Morphological and chemical properties of the copolymers produced were assessed by SEM, Morphologi G3 and FTIR analyses. Non-molecularly imprinted polymer (NIP) matrices presented swelling over time in opposition to the molecularly imprinted ones. In the scCO2-impregnation process, MIPs showed a significant molecular recognition towards MZ, presenting higher drug uptake ability with MZ loading of 18-61 wt% in MIPs, compared to 7–20 wt% in NIPs. In vitro drug release experiments presented different release profiles at the different pHs, where MZ-MIPs could release higher amounts of MZ at the lowest pH than at pH 7.4.
KW - Crosslinked polymer
KW - Metronidazole
KW - Molecular imprinting
KW - pH-responsive
KW - Supercritical carbon dioxide
UR - http://www.scopus.com/inward/record.url?scp=85043587632&partnerID=8YFLogxK
U2 - 10.1016/j.ijpharm.2018.03.010
DO - 10.1016/j.ijpharm.2018.03.010
M3 - Article
C2 - 29526621
AN - SCOPUS:85043587632
SN - 0378-5173
VL - 542
SP - 125
EP - 131
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1-2
ER -