Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers: results from the “European Human Biomonitoring Initiative” HBM4EU participating studies

Sandra F. Fernández, Michael Poteser, Eva Govarts, Olga Pardo, Clara Coscollà, Thomas Schettgen, Nina Vogel, Till Weber, Aline Murawski, Marike Kolossa-Gehring, Maria Rüther, Phillipp Schmidt, Sónia Namorado, An Van Nieuwenhuyse, Brice Appenzeller, Kristín Ólafsdóttir, Thorhallur I. Halldorsson, Line S. Haug, Cathrine Thomsen, Fabio BarboneMarika Mariuz, Valentina Rosolen, Loïc Rambaud, Margaux Riou, Thomas Göen, Stefanie Nübler, Moritz Schäfer, Karin H.A. Zarrabi, Ovnair Sepai, Laura Rodriguez Martin, Greet Schoeters, Liese Gilles, Karin Leander, Hanns Moshammer, Agneta Akesson, Federica Laguzzi

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Abstract

Little is known about exposure determinants of acrylamide (AA), a genotoxic food-processing contaminant, in Europe. We assessed determinants of AA exposure, measured by urinary mercapturic acids of AA (AAMA) and glycidamide (GAMA), its main metabolite, in 3157 children/adolescents and 1297 adults in the European Human Biomonitoring Initiative. Harmonized individual-level questionnaires data and quality assured measurements of AAMA and GAMA (urine collection: 2014–2021), the short-term validated biomarkers of AA exposure, were obtained from four studies (Italy, France, Germany, and Norway) in children/adolescents (age range: 3–18 years) and six studies (Portugal, Spain, France, Germany, Luxembourg, and Iceland) in adults (age range: 20–45 years). Multivariable-adjusted pooled quantile regressions were employed to assess median differences (β coefficients) with 95% confidence intervals (95% CI) in AAMA and GAMA (µg/g creatinine) in relation to exposure determinants. Southern European studies had higher AAMA than Northern studies. In children/adolescents, we observed significant lower AA associated with high socioeconomic status (AAMA:β = − 9.1 µg/g creatinine, 95% CI − 15.8, − 2.4; GAMA: β = − 3.4 µg/g creatinine, 95% CI − 4.7, − 2.2), living in rural areas (AAMA:β = − 4.7 µg/g creatinine, 95% CI − 8.6, − 0.8; GAMA:β = − 1.1 µg/g creatinine, 95% CI − 1.9, − 0.4) and increasing age (AAMA:β = − 1.9 µg/g creatinine, 95% CI − 2.4, − 1.4; GAMA:β = − 0.7 µg/g creatinine, 95% CI − 0.8, − 0.6). In adults, higher AAMA was also associated with high consumption of fried potatoes whereas lower AAMA was associated with higher body-mass-index. Based on this large-scale study, several potential determinants of AA exposure were identified in children/adolescents and adults in European countries.

Original languageEnglish
Article number21291
JournalScientific Reports
Volume13
Issue number1
DOIs
Publication statusPublished - Dec 2023

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