TY - JOUR
T1 - Design of controlled release systems for THEDES - Therapeutic deep eutectic solvents, using supercritical fluid technology
AU - Aroso, Ivo M.
AU - Craveiro, Rita
AU - Rocha, Ângelo
AU - Andrade, Maria Madalena Alves Campos de Sousa Dionísio
AU - Barreiros, Susana
AU - Reis, Rui L.
AU - Paiva, Alexandre
AU - Duarte, Ana Rita C
N1 - Sem PDF.
Fundacao para a Ciencia e a Tecnologia (PTDC/EQU-EPR/12191/2010/ENIGMA; SFRH/BPD/44946/2008; SFRH/BD/93049/2013);
projects ENIGMA from the European Union's Seventh Framework Programme (FP7)(PTDC/EQU-EPR/121491/2010; PTDC/QUI-QUI/119210/2010; PTDC/EQU-EQU/122106/2010; PEst-C/EQB/LA0006/2013; REGPOT - CT2012-316331-POLARIS);
Project "Novel smart and biomimetic materials for innovative regenerative medicine approaches (RL1 - ABMR - NORTE-01-0124-FEDER-000016);
North Portugal Regional Operational Programme (ON. 2-O Novo Norte), under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF).
PY - 2015
Y1 - 2015
N2 - Abstract Deep eutectic solvents (DES) can be formed by bioactive compounds or pharmaceutical ingredients. A therapeutic DES (THEDES) based on ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), and menthol was synthesized and its thermal behavior was analyzed by differential scanning calorimetry (DSC). A controlled drug delivery system was developed by impregnating a starch:poly-Ïμ-caprolactone polymeric blend (SPCL 30:70) with the menthol:ibuprofen THEDES in different ratios (10 and 20 wt%), after supercritical fluid sintering at 20 MPa and 50 °C. The morphological characterization of SPCL matrices impregnated with THEDES was performed by scanning electron microscopy (SEM) and micro-computed tomography (micro-CT). Drug release studies were carried out in a phosphate buffered saline. The results obtained provide important clues for the development of carriers for the sustainable delivery of bioactive compounds.
AB - Abstract Deep eutectic solvents (DES) can be formed by bioactive compounds or pharmaceutical ingredients. A therapeutic DES (THEDES) based on ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), and menthol was synthesized and its thermal behavior was analyzed by differential scanning calorimetry (DSC). A controlled drug delivery system was developed by impregnating a starch:poly-Ïμ-caprolactone polymeric blend (SPCL 30:70) with the menthol:ibuprofen THEDES in different ratios (10 and 20 wt%), after supercritical fluid sintering at 20 MPa and 50 °C. The morphological characterization of SPCL matrices impregnated with THEDES was performed by scanning electron microscopy (SEM) and micro-computed tomography (micro-CT). Drug release studies were carried out in a phosphate buffered saline. The results obtained provide important clues for the development of carriers for the sustainable delivery of bioactive compounds.
KW - Biodegradable polymers
KW - Drug delivery systems
KW - Ibuprofen
KW - Supercritical carbon dioxide
KW - Therapeutic deep eutectic solvents
UR - http://www.scopus.com/inward/record.url?scp=84937214605&partnerID=8YFLogxK
U2 - 10.1016/j.ijpharm.2015.06.038
DO - 10.1016/j.ijpharm.2015.06.038
M3 - Article
C2 - 26142248
AN - SCOPUS:84937214605
SN - 0378-5173
VL - 492
SP - 73
EP - 79
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1-2
M1 - 14990
ER -