TY - JOUR
T1 - Dermic diffusion and stratum corneum: A state of the art review of mathematical models.
AU - Ribeiro, Rogério José Tavares
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Transdermal biotechnologies are an ever increasing field of interest, due to the medical and pharmaceutical applications that they underlie. There are several mathematical models at use that permit a more inclusive vision of pure experimental data and even allow practical extrapolation for new dermal diffusion methodologies. However, they grasp a complex variety of theories and assumptions that allocate their use for specific situations. Models based on Fick's First Law found better use in contexts where scaled particle theory Models would be extensive in time-span but the reciprocal is also true, as context of transdermal diffusion of particular active compounds changes. This article reviews extensively the various theoretical methodologies for studying dermic diffusion in the rate limiting dermic barrier, the stratum corneum, and systematizes its characteristics, their proper context of application, advantages and limitations, as well as future perspectives.
AB - Transdermal biotechnologies are an ever increasing field of interest, due to the medical and pharmaceutical applications that they underlie. There are several mathematical models at use that permit a more inclusive vision of pure experimental data and even allow practical extrapolation for new dermal diffusion methodologies. However, they grasp a complex variety of theories and assumptions that allocate their use for specific situations. Models based on Fick's First Law found better use in contexts where scaled particle theory Models would be extensive in time-span but the reciprocal is also true, as context of transdermal diffusion of particular active compounds changes. This article reviews extensively the various theoretical methodologies for studying dermic diffusion in the rate limiting dermic barrier, the stratum corneum, and systematizes its characteristics, their proper context of application, advantages and limitations, as well as future perspectives.
KW - Fick's Law
KW - SYNTHETIC MEMBRANE-VESICLES
KW - TRANSDERMAL DRUG-DELIVERY
KW - VACCINE DELIVERY
KW - Mathematical diffusion models
KW - MOLECULAR-DYNAMICS
KW - (TRANS)DERMAL DRUG
KW - Sensors
KW - OLEIC-ACIDInformaçoes sobre autores
KW - Hybrid approach
KW - HUMAN SKIN
KW - PENETRATION ENHANCERS
KW - Transdermal diffusion
KW - IN-VIVO
KW - STUDYING IMPACT
U2 - 10.1016/j.jconrel.2013.12.005
DO - 10.1016/j.jconrel.2013.12.005
M3 - Article
C2 - 24362041
VL - 177C
SP - 74
EP - 83
JO - Journal Of Controlled Release
JF - Journal Of Controlled Release
SN - 0168-3659
IS - NA
ER -