Dereplication: Racing to speed up the natural products discovery process

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136 Citations (Scopus)

Abstract

Covering: 1993-2014 (July) To alleviate the dereplication holdup, which is a major bottleneck in natural products discovery, scientists have been conducting their research efforts to add tools to their "bag of tricks" aiming to achieve faster, more accurate and efficient ways to accelerate the pace of the drug discovery process. Consequently dereplication has become a hot topic presenting a huge publication boom since 2012, blending multidisciplinary fields in new ways that provide important conceptual and/or methodological advances, opening up pioneering research prospects in this field. This journal is

Original languageEnglish
Pages (from-to)779-810
Number of pages32
JournalNatural Product Reports
Volume32
Issue number6
DOIs
Publication statusPublished - 1 Jun 2015

Keywords

  • ASSISTED STRUCTURE ELUCIDATION
  • NUCLEAR-MAGNETIC-RESONANCE
  • FLIGHT-MASS-SPECTROMETRY
  • PRESSURE LIQUID-CHROMATOGRAPHY
  • 2D NMR DATA
  • SECONDARY-METABOLITE BIOSYNTHESIS
  • AUTOMATED STRUCTURE ELUCIDATION
  • DIFFUSION-ORDERED SPECTROSCOPY
  • ENHANCED STRUCTURE ELUCIDATION
  • SOLID-PHASE EXTRACTION

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