Dereplication: Racing to speed up the natural products discovery process

Susana Maria Pereira Gaudêncio de Matos; Florbela Pereira

doi:10.1039/c4np00134f

Dereplication: Racing to speed up the natural products discovery process

Susana Maria Pereira Gaudêncio de Matos, Florbela Pereira

Research output: Contribution to journal › Review article › peer-review

205 Citations (Scopus)

Abstract

Covering: 1993-2014 (July) To alleviate the dereplication holdup, which is a major bottleneck in natural products discovery, scientists have been conducting their research efforts to add tools to their "bag of tricks" aiming to achieve faster, more accurate and efficient ways to accelerate the pace of the drug discovery process. Consequently dereplication has become a hot topic presenting a huge publication boom since 2012, blending multidisciplinary fields in new ways that provide important conceptual and/or methodological advances, opening up pioneering research prospects in this field. This journal is

Original language	English
Pages (from-to)	779-810
Number of pages	32
Journal	Natural Product Reports
Volume	32
Issue number	6
DOIs	https://doi.org/10.1039/c4np00134f
Publication status	Published - 1 Jun 2015

Keywords

ASSISTED STRUCTURE ELUCIDATION
NUCLEAR-MAGNETIC-RESONANCE
FLIGHT-MASS-SPECTROMETRY
PRESSURE LIQUID-CHROMATOGRAPHY
2D NMR DATA
SECONDARY-METABOLITE BIOSYNTHESIS
AUTOMATED STRUCTURE ELUCIDATION
DIFFUSION-ORDERED SPECTROSCOPY
ENHANCED STRUCTURE ELUCIDATION
SOLID-PHASE EXTRACTION

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abstract = "Covering: 1993-2014 (July) To alleviate the dereplication holdup, which is a major bottleneck in natural products discovery, scientists have been conducting their research efforts to add tools to their {"}bag of tricks{"} aiming to achieve faster, more accurate and efficient ways to accelerate the pace of the drug discovery process. Consequently dereplication has become a hot topic presenting a huge publication boom since 2012, blending multidisciplinary fields in new ways that provide important conceptual and/or methodological advances, opening up pioneering research prospects in this field. This journal is",

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author = "Matos, {Susana Maria Pereira Gaud{\^e}ncio de} and Florbela Pereira",

note = "Fundacao para a Ciencia e a Tecnologia (FCT), Ministerio da Educacao e Ciencia, Portugal and FEDER through grant no. PTDC/QUI-QUI/119116/2010, PEst-C/EQB/LA0006/2013 and PEst-OE/BIA/UI0457/2011-CREM, and the European Union 7th Framework Programme (FP7/2007-2013) under grant agreement no. PCOFUND-GA-2009-246542.",

year = "2015",

month = jun,

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doi = "10.1039/c4np00134f",

language = "English",

volume = "32",

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AB - Covering: 1993-2014 (July) To alleviate the dereplication holdup, which is a major bottleneck in natural products discovery, scientists have been conducting their research efforts to add tools to their "bag of tricks" aiming to achieve faster, more accurate and efficient ways to accelerate the pace of the drug discovery process. Consequently dereplication has become a hot topic presenting a huge publication boom since 2012, blending multidisciplinary fields in new ways that provide important conceptual and/or methodological advances, opening up pioneering research prospects in this field. This journal is

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KW - 2D NMR DATA

KW - SECONDARY-METABOLITE BIOSYNTHESIS

KW - AUTOMATED STRUCTURE ELUCIDATION

KW - DIFFUSION-ORDERED SPECTROSCOPY

KW - ENHANCED STRUCTURE ELUCIDATION

KW - SOLID-PHASE EXTRACTION

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JO - Natural Product Reports

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Dereplication: Racing to speed up the natural products discovery process

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Keywords

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