Dendritic Cells show evidence of a cell suface Sialyltransferase activity

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Abstract

Human monocyte-derived dendritic cells (mo-DCs) express highly sialylated structures, with a recognized role in maturation, immoneginicity and endocytosis capacity. Here, we demonstrated that, in the presence of exogenous CMP-Neu, mo-DC's significantly incorporated sialic acid into cell surface, especially after sialidase treatment and upon inaturation. This atypical cell membrane siatyltransferase activity it by a sialyltransferase inhibitor the CTP, and it was not influenced by secreted enzymes. All the functional level, this ectosialyltransferase activity the endocytosis capacity of mo-DCs. as demonstrated by the down-regulation of ovalbumin uptake. These eclosially transferases seem to participate in a dynamic cannot of mo-DC sialylation probably contributing to protection and homeostasis regulation an it limy serve as a therapeutic target.
Original languageUnknown
Title of host publication2ND EUROPEAN CONGRESS OF IMMUNOLOGY (ECI)
Pages11-16
Volume1
Publication statusPublished - 1 Jan 2009
Event2nd European Congress of Immunology (ECI) -
Duration: 1 Jan 2009 → …

Conference

Conference2nd European Congress of Immunology (ECI)
Period1/01/09 → …

Cite this

Videira, P. A., & Cabral, M. G. (2009). Dendritic Cells show evidence of a cell suface Sialyltransferase activity. In 2ND EUROPEAN CONGRESS OF IMMUNOLOGY (ECI) (Vol. 1, pp. 11-16)