Human monocyte-derived dendritic cells (mo-DCs) express highly sialylated structures, with a recognized role in maturation, immoneginicity and endocytosis capacity. Here, we demonstrated that, in the presence of exogenous CMP-Neu, mo-DC's significantly incorporated sialic acid into cell surface, especially after sialidase treatment and upon inaturation. This atypical cell membrane siatyltransferase activity it by a sialyltransferase inhibitor the CTP, and it was not influenced by secreted enzymes. All the functional level, this ectosialyltransferase activity the endocytosis capacity of mo-DCs. as demonstrated by the down-regulation of ovalbumin uptake. These eclosially transferases seem to participate in a dynamic cannot of mo-DC sialylation probably contributing to protection and homeostasis regulation an it limy serve as a therapeutic target.
|Title of host publication||2ND EUROPEAN CONGRESS OF IMMUNOLOGY (ECI)|
|Publication status||Published - 1 Jan 2009|
|Event||2nd European Congress of Immunology (ECI) - |
Duration: 1 Jan 2009 → …
|Conference||2nd European Congress of Immunology (ECI)|
|Period||1/01/09 → …|