Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity

Inês Castela; Juliana Morais; Inês Barreiros-Mota; Marta P Silvestre; Cláudia Marques; Catarina Rodrigues; Shámila Ismael; João R Araújo; Miguel Ângelo-Dias; Catarina Martins; Luís Miguel Borrego; Rosário Monteiro; Silvia Ribeiro Coutinho; Conceição Calhau; Catia Martins; Ana Faria; Diogo Pestana; Diana Teixeira

doi:10.1152/ajpendo.00273.2022

Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity

Inês Castela, Juliana Morais, Inês Barreiros-Mota, Marta P Silvestre, Cláudia Marques, Catarina Rodrigues, Shámila Ismael, João R Araújo, Miguel Ângelo-Dias, Catarina Martins, Luís Miguel Borrego, Rosário Monteiro, Silvia Ribeiro Coutinho, Conceição Calhau, Catia Martins, Ana Faria, Diogo Pestana, Diana Teixeira

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Adipose tissue dysfunction is a key mechanism that leads to adiposity-based chronic disease. This study aimed to investigate the feasibility of the adiponectin/leptin ratio (AdipoQ/Lep) as an adipose tissue and metabolic function biomarker in adults with obesity, without diabetes. Data were collected from a clinical trial conducted in 28 adults with obesity (mean body mass index: 35.4±3.7 kg/m2) (NCT02169778). Using a forward stepwise multiple linear regression model to explore the relationship between AdipoQ/Lep and HOMA-IR, it was observed that 48.6% of HOMA-IR variance was explained by triacylglycerols, AdipoQ/Lep and waist-to-hip ratio (P<0.001), being AdipoQ/Lep the strongest independent predictor (Beta = -0.449, P<0.001). A lower AdipoQ/Lep was correlated with a higher body mass index (Rs = -0.490, P<0.001), body fat mass (Rs = -0.486, P<0.001), waist-to-height ratio (RS = -0.290, P=0.037), and plasma resistin (Rs = -0.365, P=0.009). These data highlight the central role of adipocyte dysfunction in the pathogenesis of insulin resistance and emphasize that AdipoQ/Lep may be a promising early marker of insulin resistance development in adults with obesity.

Original language	English
Pages (from-to)	E115 - E119
Journal	American journal of physiology. Endocrinology and metabolism
Volume	324
Issue number	2
Early online date	9 Nov 2022
DOIs	https://doi.org/10.1152/ajpendo.00273.2022
Publication status	Published - 1 Feb 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

adiponectin/leptin
adipose tissue dysfunction
insulin resistance
metabolic dysfunction
obesity

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10.1152/ajpendo.00273.2022

Cite this

Castela, I., Morais, J., Barreiros-Mota, I., Silvestre, M. P., Marques, C., Rodrigues, C., Ismael, S., Araújo, J. R., Ângelo-Dias, M., Martins, C., Borrego, L. M., Monteiro, R., Coutinho, S. R., Calhau, C., Martins, C., Faria, A., Pestana, D., & Teixeira, D. (2023). Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity. American journal of physiology. Endocrinology and metabolism, 324(2), E115 - E119. https://doi.org/10.1152/ajpendo.00273.2022

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title = "Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity",

abstract = "Adipose tissue dysfunction is a key mechanism that leads to adiposity-based chronic disease. This study aimed to investigate the feasibility of the adiponectin/leptin ratio (AdipoQ/Lep) as an adipose tissue and metabolic function biomarker in adults with obesity, without diabetes. Data were collected from a clinical trial conducted in 28 adults with obesity (mean body mass index: 35.4±3.7 kg/m2) (NCT02169778). Using a forward stepwise multiple linear regression model to explore the relationship between AdipoQ/Lep and HOMA-IR, it was observed that 48.6\% of HOMA-IR variance was explained by triacylglycerols, AdipoQ/Lep and waist-to-hip ratio (P<0.001), being AdipoQ/Lep the strongest independent predictor (Beta = -0.449, P<0.001). A lower AdipoQ/Lep was correlated with a higher body mass index (Rs = -0.490, P<0.001), body fat mass (Rs = -0.486, P<0.001), waist-to-height ratio (RS = -0.290, P=0.037), and plasma resistin (Rs = -0.365, P=0.009). These data highlight the central role of adipocyte dysfunction in the pathogenesis of insulin resistance and emphasize that AdipoQ/Lep may be a promising early marker of insulin resistance development in adults with obesity.",

keywords = "adiponectin/leptin, adipose tissue dysfunction, insulin resistance, metabolic dysfunction, obesity",

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doi = "10.1152/ajpendo.00273.2022",

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Castela, I , Morais, J , Barreiros-Mota, I , Silvestre, MP , Marques, C , Rodrigues, C , Ismael, S , Araújo, JR , Ângelo-Dias, M , Martins, C , Borrego, LM, Monteiro, R, Coutinho, SR, Calhau, C, Martins, C, Faria, A , Pestana, D & Teixeira, D 2023, 'Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity', American journal of physiology. Endocrinology and metabolism, vol. 324, no. 2, pp. E115 - E119. https://doi.org/10.1152/ajpendo.00273.2022

TY - JOUR

T1 - Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity

AU - Castela, Inês

AU - Morais, Juliana

AU - Barreiros-Mota, Inês

AU - Silvestre, Marta P

AU - Marques, Cláudia

AU - Rodrigues, Catarina

AU - Ismael, Shámila

AU - Araújo, João R

AU - Ângelo-Dias, Miguel

AU - Martins, Catarina

AU - Borrego, Luís Miguel

AU - Monteiro, Rosário

AU - Coutinho, Silvia Ribeiro

AU - Calhau, Conceição

AU - Martins, Catia

AU - Faria, Ana

AU - Pestana, Diogo

AU - Teixeira, Diana

PY - 2023/2/1

Y1 - 2023/2/1

N2 - Adipose tissue dysfunction is a key mechanism that leads to adiposity-based chronic disease. This study aimed to investigate the feasibility of the adiponectin/leptin ratio (AdipoQ/Lep) as an adipose tissue and metabolic function biomarker in adults with obesity, without diabetes. Data were collected from a clinical trial conducted in 28 adults with obesity (mean body mass index: 35.4±3.7 kg/m2) (NCT02169778). Using a forward stepwise multiple linear regression model to explore the relationship between AdipoQ/Lep and HOMA-IR, it was observed that 48.6% of HOMA-IR variance was explained by triacylglycerols, AdipoQ/Lep and waist-to-hip ratio (P<0.001), being AdipoQ/Lep the strongest independent predictor (Beta = -0.449, P<0.001). A lower AdipoQ/Lep was correlated with a higher body mass index (Rs = -0.490, P<0.001), body fat mass (Rs = -0.486, P<0.001), waist-to-height ratio (RS = -0.290, P=0.037), and plasma resistin (Rs = -0.365, P=0.009). These data highlight the central role of adipocyte dysfunction in the pathogenesis of insulin resistance and emphasize that AdipoQ/Lep may be a promising early marker of insulin resistance development in adults with obesity.

AB - Adipose tissue dysfunction is a key mechanism that leads to adiposity-based chronic disease. This study aimed to investigate the feasibility of the adiponectin/leptin ratio (AdipoQ/Lep) as an adipose tissue and metabolic function biomarker in adults with obesity, without diabetes. Data were collected from a clinical trial conducted in 28 adults with obesity (mean body mass index: 35.4±3.7 kg/m2) (NCT02169778). Using a forward stepwise multiple linear regression model to explore the relationship between AdipoQ/Lep and HOMA-IR, it was observed that 48.6% of HOMA-IR variance was explained by triacylglycerols, AdipoQ/Lep and waist-to-hip ratio (P<0.001), being AdipoQ/Lep the strongest independent predictor (Beta = -0.449, P<0.001). A lower AdipoQ/Lep was correlated with a higher body mass index (Rs = -0.490, P<0.001), body fat mass (Rs = -0.486, P<0.001), waist-to-height ratio (RS = -0.290, P=0.037), and plasma resistin (Rs = -0.365, P=0.009). These data highlight the central role of adipocyte dysfunction in the pathogenesis of insulin resistance and emphasize that AdipoQ/Lep may be a promising early marker of insulin resistance development in adults with obesity.

KW - adiponectin/leptin

KW - adipose tissue dysfunction

KW - insulin resistance

KW - metabolic dysfunction

KW - obesity

U2 - 10.1152/ajpendo.00273.2022

DO - 10.1152/ajpendo.00273.2022

M3 - Article

C2 - 36351292

SN - 0193-1849

VL - 324

SP - E115 - E119

JO - American journal of physiology. Endocrinology and metabolism

JF - American journal of physiology. Endocrinology and metabolism

IS - 2

ER -

Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity

Abstract

UN SDGs

Keywords

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