TY - JOUR
T1 - Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity
AU - Castela, Inês
AU - Morais, Juliana
AU - Barreiros-Mota, Inês
AU - Silvestre, Marta P
AU - Marques, Cláudia
AU - Rodrigues, Catarina
AU - Ismael, Shámila
AU - Araújo, João R
AU - Ângelo-Dias, Miguel
AU - Martins, Catarina
AU - Borrego, Luís Miguel
AU - Monteiro, Rosário
AU - Coutinho, Silvia Ribeiro
AU - Calhau, Conceição
AU - Martins, Catia
AU - Faria, Ana
AU - Pestana, Diogo
AU - Teixeira, Diana
PY - 2023/2/1
Y1 - 2023/2/1
N2 - Adipose tissue dysfunction is a key mechanism that leads to adiposity-based chronic disease. This study aimed to investigate the feasibility of the adiponectin/leptin ratio (AdipoQ/Lep) as an adipose tissue and metabolic function biomarker in adults with obesity, without diabetes. Data were collected from a clinical trial conducted in 28 adults with obesity (mean body mass index: 35.4±3.7 kg/m2) (NCT02169778). Using a forward stepwise multiple linear regression model to explore the relationship between AdipoQ/Lep and HOMA-IR, it was observed that 48.6% of HOMA-IR variance was explained by triacylglycerols, AdipoQ/Lep and waist-to-hip ratio (P<0.001), being AdipoQ/Lep the strongest independent predictor (Beta = -0.449, P<0.001). A lower AdipoQ/Lep was correlated with a higher body mass index (Rs = -0.490, P<0.001), body fat mass (Rs = -0.486, P<0.001), waist-to-height ratio (RS = -0.290, P=0.037), and plasma resistin (Rs = -0.365, P=0.009). These data highlight the central role of adipocyte dysfunction in the pathogenesis of insulin resistance and emphasize that AdipoQ/Lep may be a promising early marker of insulin resistance development in adults with obesity.
AB - Adipose tissue dysfunction is a key mechanism that leads to adiposity-based chronic disease. This study aimed to investigate the feasibility of the adiponectin/leptin ratio (AdipoQ/Lep) as an adipose tissue and metabolic function biomarker in adults with obesity, without diabetes. Data were collected from a clinical trial conducted in 28 adults with obesity (mean body mass index: 35.4±3.7 kg/m2) (NCT02169778). Using a forward stepwise multiple linear regression model to explore the relationship between AdipoQ/Lep and HOMA-IR, it was observed that 48.6% of HOMA-IR variance was explained by triacylglycerols, AdipoQ/Lep and waist-to-hip ratio (P<0.001), being AdipoQ/Lep the strongest independent predictor (Beta = -0.449, P<0.001). A lower AdipoQ/Lep was correlated with a higher body mass index (Rs = -0.490, P<0.001), body fat mass (Rs = -0.486, P<0.001), waist-to-height ratio (RS = -0.290, P=0.037), and plasma resistin (Rs = -0.365, P=0.009). These data highlight the central role of adipocyte dysfunction in the pathogenesis of insulin resistance and emphasize that AdipoQ/Lep may be a promising early marker of insulin resistance development in adults with obesity.
U2 - 10.1152/ajpendo.00273.2022
DO - 10.1152/ajpendo.00273.2022
M3 - Article
C2 - 36351292
SP - E115 - E119
JO - American Journal Of Physiology-Endocrinology And Metabolism
JF - American Journal Of Physiology-Endocrinology And Metabolism
SN - 0193-1849
ER -
