D-α-tocopheryl polyethylene glycol 1000 succinate functionalized nanographene oxide for cancer therapy

Duarte De Melo-Diogo, Cleide Pais-Silva, Ricardo O. Louro

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Aim: To evaluate the therapeutic capacity of D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)-functionalized nanographene oxide (nGO) in breast cancer cells. Methods: TPGS-functionalized nGO-based materials were obtained through two different approaches: a simple sonication method and a one-pot hydrothermal treatment. Results: TPGS coating successfully improved the stability of the nGO-based materials. The nanomaterials that underwent the hydrothermal procedure generated a 1.4- to 1.6-fold higher temperature variation under near infrared laser irradiation than those prepared only by sonication. In vitro, the TPGS/nGO derivatives reduced breast cancer cells' viability and had an insignificant effect on healthy cells. Furthermore, the combined application of TPGS/nGO derivatives and near infrared light generated an improved therapeutic effect. Conclusion: TPGS/nGO derivatives are promising materials for breast cancer phototherapy.

Original languageEnglish
Pages (from-to)443-456
Number of pages14
JournalNanomedicine
Volume12
Issue number5
DOIs
Publication statusPublished - 1 Mar 2017

Keywords

  • breast cancer
  • nanographene oxide
  • PEGylated Vitamin E
  • phototherapy
  • TPGS

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