@article{09f8862a478846758575e0b70fd73eed,
title = "Cyclam-based iron(iii) and copper(ii) complexes: synthesis, characterization and application as antifungal agents",
abstract = "New cyclam-based complexes of formulae [{H2(4-CF3PhCH2)2Cyclam}FeCl2]Cl and [{H2(4-CF3PhCH2)2Cyclam}Cu](CH3COO)2·2H2O were synthesized, in very high yields, by the reaction of H2(4-CF3PhCH2)2Cyclam with the corresponding metal salts in methanol. [{H2(4-CF3PhCH2)2Cyclam}FeCl2]Cl was also prepared, quantitatively, in the solid state by mechanochemistry. The M{\"o}ssbauer spectra of [{H2(4-CF3PhCH2)2Cyclam}FeCl2]Cl show that the high-spin cis complex is the major product of both reactions. The EPR data of [{H2(4-CF3PhCH2)2Cyclam}Cu](CH3COO)2·2H2O are consistent with two distinct Cu2+ species, whose solid state molecular structures were determined by single crystal X-ray diffraction and correspond to complexes displaying octahedral and square-pyramidal geometries. The screening of the antifungal activity of both metal complexes revealed the higher activity of [{H2(4-CF3PhCH2)2Cyclam}FeCl2]Cl to inhibit the growth of unicellular and multicellular fungal species with described pathogenic potential.",
keywords = "Antifungal agents, Copper compounds, Electron spin resonance spectroscopy, Fungi, Iron compounds, Metal complexes, Single crystals, Antifungals, Copper complexes, High spins, Higher yield, Mechano-chemistry, Metal salt, Mossbauer spectra, Solid-state molecular structure, Synthesised, X- ray diffractions, Synthesis (chemical)",
author = "Stephanie Almada and Maia, {Lu{\'i}sa B.} and Waerenborgh, {Jo{\~a}o C.} and Vieira, {Bruno J. C.} and Mira, {Nuno P.} and {R. Silva}, Elisabete and F{\'a}tima Cerqueira and Eug{\'e}nia Pinto and Alves, {Lu{\'i}s G.}",
note = "Funding Information: info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FQUI-QIN%2F32240%2F2017/PT# info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04349%2F2013/PT# info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00100%2F2020/PT# info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT# info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT# info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04423%2F2020/PT# info:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F03810%2F2017%2FCP1462%2FCT0017/PT# info:eu-repo/grantAgreement/FCT/CEEC IND 2018/CEECIND%2F03530%2F2018%2FCP1553%2FCT0011/PT# The authors acknowledge the financial support from the Research Center of the Portuguese Oncology Institute of Porto (project no. PI86-CI-IPOP-66-2019) and the Funda{\c c}{\~a}o para a Ci{\^e}ncia e a Tecnologia, Portugal, within the funding projects LA/P/0056/2020. Luisa B. Maia and Elisabete R. Silva also acknowledge the Funda{\c c}{\~a}o para a Ci{\^e}ncia e a Tecnologia, Portugal, for the work contracts through the Scientific Employment Stimulus Individual Calls, an respectively. The National Infrastructure Roadmap, LTHMFL-NECL and LISBOA-01-0145-FEDER-022096, is also anknowledged. C. albicans H37 and C. krusei H9 were courtesy of Cid{\'a}lia Pina Vaz from Centro Hospitalar S{\~a}o Jo{\~a}o, Portugal, and C. glabrata DSY562 and DSY565 were courtesy of D. Sanglard from the University of Lausanne, Switzerland. Publisher Copyright: {\textcopyright} 2022 The Royal Society of Chemistry.",
year = "2022",
month = aug,
day = "3",
doi = "10.1039/d2nj03161b",
language = "English",
pages = "16764–16770 ",
journal = "New Journal of Chemistry",
issn = "1144-0546",
publisher = "RSC - Royal Society of Chemistry",
number = "46",
}