Cyclam-based iron(iii) and copper(ii) complexes: synthesis, characterization and application as antifungal agents

Stephanie Almada, Luísa B. Maia, João C. Waerenborgh, Bruno J. C. Vieira, Nuno P. Mira, Elisabete R. Silva, Fátima Cerqueira, Eugénia Pinto, Luís G. Alves

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

New cyclam-based complexes of formulae [{H2(4-CF3PhCH2)2Cyclam}FeCl2]Cl and [{H2(4-CF3PhCH2)2Cyclam}Cu](CH3COO)2·2H2O were synthesized, in very high yields, by the reaction of H2(4-CF3PhCH2)2Cyclam with the corresponding metal salts in methanol. [{H2(4-CF3PhCH2)2Cyclam}FeCl2]Cl was also prepared, quantitatively, in the solid state by mechanochemistry. The Mössbauer spectra of [{H2(4-CF3PhCH2)2Cyclam}FeCl2]Cl show that the high-spin cis complex is the major product of both reactions. The EPR data of [{H2(4-CF3PhCH2)2Cyclam}Cu](CH3COO)2·2H2O are consistent with two distinct Cu2+ species, whose solid state molecular structures were determined by single crystal X-ray diffraction and correspond to complexes displaying octahedral and square-pyramidal geometries. The screening of the antifungal activity of both metal complexes revealed the higher activity of [{H2(4-CF3PhCH2)2Cyclam}FeCl2]Cl to inhibit the growth of unicellular and multicellular fungal species with described pathogenic potential.

Original languageEnglish
Pages (from-to)16764–16770
Number of pages7
JournalNew Journal of Chemistry
Issue number46
DOIs
Publication statusPublished - 3 Aug 2022

Keywords

  • Antifungal agents
  • Copper compounds
  • Electron spin resonance spectroscopy
  • Fungi
  • Iron compounds
  • Metal complexes
  • Single crystals
  • Antifungals
  • Copper complexes
  • High spins
  • Higher yield
  • Mechano-chemistry
  • Metal salt
  • Mossbauer spectra
  • Solid-state molecular structure
  • Synthesised
  • X- ray diffractions
  • Synthesis (chemical)

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