TY - JOUR
T1 - Crosslinked bacterial cellulose hydrogels for biomedical applications
AU - Almeida, Ana P. C.
AU - Saraiva, João N.
AU - Cavaco, Gonçalo
AU - Portela, Raquel P.
AU - Leal, Catarina R.
AU - Sobral, Rita G.
AU - Almeida, Pedro L.
N1 - info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04378%2F2020/PT#
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT#
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0140%2F2020/PT#
info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-MIC%2F31645%2F2017/PT#
Funding Information:
Funding : This study was funded by by National funds from FCT - Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project reference UID/CTM/50025/2020 of the Research Unit CENIMAT – I3N.
Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/8/15
Y1 - 2022/8/15
N2 - Recently, increasing attention has been given to bacterial cellulose-based membranes to be applied as dressings for healing purposes. Bacterial cellulose (BC) is an attractive biomaterial due to its unique structural characteristics such as high porosity, high water retention capacity, high mechanical strength, low density, and biodegradability. One drawback of bacterial cellulose hydrogels is that, after the first dehydration, the water retention capacity is hindered. In this work we produced, modified, and characterized hydrated and de-hydrated BC membranes for biomedical applications. Two crosslinking methods were adopted (using citric acid and epichlorohydrin as crosslinking agents), and the results obtained from the characterization, such as water retention capacity, mechanical properties or contact angle, were compared to those of unmodified bacterial cellulose. We demonstrate that the cross-linked bacterial cellulose membranes present physical properties suitable to be used as wound dressings when hydrated, or as exuding wound dressings, when dehydrated.
AB - Recently, increasing attention has been given to bacterial cellulose-based membranes to be applied as dressings for healing purposes. Bacterial cellulose (BC) is an attractive biomaterial due to its unique structural characteristics such as high porosity, high water retention capacity, high mechanical strength, low density, and biodegradability. One drawback of bacterial cellulose hydrogels is that, after the first dehydration, the water retention capacity is hindered. In this work we produced, modified, and characterized hydrated and de-hydrated BC membranes for biomedical applications. Two crosslinking methods were adopted (using citric acid and epichlorohydrin as crosslinking agents), and the results obtained from the characterization, such as water retention capacity, mechanical properties or contact angle, were compared to those of unmodified bacterial cellulose. We demonstrate that the cross-linked bacterial cellulose membranes present physical properties suitable to be used as wound dressings when hydrated, or as exuding wound dressings, when dehydrated.
KW - Bacterial cellulose
KW - Biomaterials
KW - Biomedical applications
KW - Crosslinking
KW - Wound dressings
UR - http://www.scopus.com/inward/record.url?scp=85134886920&partnerID=8YFLogxK
U2 - 10.1016/j.eurpolymj.2022.111438
DO - 10.1016/j.eurpolymj.2022.111438
M3 - Article
AN - SCOPUS:85134886920
SN - 0014-3057
VL - 177
JO - European Polymer Journal
JF - European Polymer Journal
M1 - 111438
ER -