Cross-reactivity between Chlamydia trachomatis heat shock protein 10 and early pregnancy factor

Fotini Betsou, Maria José Borrego, Nicolas Guillaume, Maria Anjos Catry, Sandra Romão, J. A. Machado-Caetano, Jean Marie Sueur, Jacques Mention, Nicole Faille, Jeanne Orfila

Research output: Contribution to journalArticle

9 Citations (Scopus)
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Abstract

Chlamydia trachomatis heat shock protein 10 (Chsp10) is associated with chronic genital tract infection with C. trachomatis. Chsp10 is homologous to human chaperonin 10 (Cpn10) and early pregnancy factor (EPF), a form of human Cpn10 that is specifically secreted at the start of pregnancy. We investigated cross-reactions between serum anti-Chsp10 antibodies and anti-EPF antibodies in pregnant and nonpregnant patients. Pregnancy was found to be associated with the presence of anti-EPF antibodies, which are specifically induced in pregnant women with a history of C. trachomatis infection, and with the presence of serum anti-Chsp10 antibodies. We also found that infertility was associated with the presence of anti-Chsp10 and anti-EPF antibodies. The HLA class II haplotype DR8 DQ4 was associated with the presence of anti-Chsp10 antibodies but not of anti-EPF antibodies.

Original languageEnglish
Pages (from-to)446-450
Number of pages5
JournalClinical and Diagnostic Laboratory Immunology
Volume10
Issue number3
DOIs
Publication statusPublished - Jun 2003

Keywords

  • MONOCLONAL-ANTIBODIES
  • HUMAN CHAPERONIN-10
  • IDENTIFICATION
  • AUTOIMMUNITY
  • PURIFICATION
  • ALLELES
  • CLONING
  • MICE

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