Cranberry (poly)phenol metabolites correlate with improvements in vascular function: A double-blind, randomized, controlled, dose-response, crossover study

Ana Rodriguez-Mateos, Rodrigo P. Feliciano, Albert Boeres, Timon Weber, Maria Claudia Santos, Maria Rita Lima, Christian Heiss

Research output: Contribution to journalArticlepeer-review

65 Citations (Scopus)

Abstract

Scope: Cranberries are rich in potentially bioactive (poly)phenols. The aim of this paper was to investigate whether cranberry juice intake can improve vascular function in healthy men in a dose- and time-dependent manner, and to understand which of the circulating (poly)phenol metabolites correlate with vascular effects. Methods and results: A double-blind randomized controlled crossover trial was conducted in ten healthy males. Flow-mediated dilation (FMD), blood pressure, pulse wave velocity and augmentation index were investigated at baseline, 1, 2, 4, 6, and 8 h post-consumption of cranberry juices containing 409, 787, 1238, 1534, and 1910 mg of total cranberry (poly)phenols (TP), and a control drink. Plasma (poly)phenol metabolites were analyzed by UPLC-Q-TOF MS using authentic standards. We observed dose-dependent increases in FMD at 1, 2, 4, 6, and 8 h with a peak at 4 h and maximal effects with juice containing 1238 mg TP. A total of 60 metabolites were quantified in plasma after cranberry consumption. Twelve (poly)phenol metabolites significantly correlated with the increases in FMD, including ferulic and caffeic acid sulfates, quercetin-3-O-ß-D-glucuronide and a γ-valerolactone sulfate. Conclusion: (Poly)phenols in cranberry juice can improve vascular function in healthy males and this is linked to the presence of specific newly identified plasma metabolites.

Original languageEnglish
Pages (from-to)2130-2140
Number of pages11
JournalMolecular Nutrition & Food Research
Volume60
Issue number10
DOIs
Publication statusPublished - 1 Oct 2016

Keywords

  • (Poly)phenols
  • Cranberry
  • Endothelial function
  • Metabolites
  • Primary prevention

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