TY - JOUR
T1 - Cosmeceutical Potential of Extracts Derived from Fishery Industry Residues
T2 - Sardine Wastes and Codfish Frames
AU - Cardeira, Martim
AU - Bernardo, Ana
AU - Leonardo, Inês C.
AU - Gaspar, Frédéric B.
AU - Marques, Marta
AU - Melgosa, Rodrigo
AU - Paiva, Alexandre
AU - Simões, Pedro
AU - Fernández, Naiara
AU - Serra, Ana Teresa
N1 - Funding Information:
This work was funded by Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through project PTDC/ASPPES/28399/2017 and national funds iNOVA4Health (UIDB/04462/2020 and UIDP/04462/2020) and the Associate Laboratories LS4FUTURE (LA/P/0087/2020) and LAQV (UIDB/QUI/50006/2020). Funding from INTERFACE Programme, through the Innovation, Technology and Circular Economy Fund (FITEC), is gratefully acknowledged. ATS also acknowledges FCT/MCTES for the Individual Grant CEECIND/04801/2017.
Publisher Copyright:
© 2022 by the authors.
PY - 2022/10
Y1 - 2022/10
N2 - The fishery industry generates large amounts of waste (20–75% (w/w) of the total caught fish weight). The recovery of bioactive compounds from residues and their incorporation in cosmetics represents a promising market opportunity and may contribute to a sustainable valorisation of the sector. In this work, protein-rich extracts obtained by high-pressure technologies (supercritical CO2 and subcritical water) from sardine (Sardina pilchardus) waste and codfish (Gadus morhua) frames were characterized regarding their cosmeceutical potential. Antioxidant, anti-inflammatory and antibacterial activities were evaluated through chemical (ORAC assay), enzymatic (inhibition of elastase and tyrosinase), antimicrobial susceptibility (Klebsiella pneumoniae, Staphylococcus aureus and Cutibacterium acnes) and cell-based (in keratinocytes-HaCaT) assays. Sardine extracts presented the highest antibacterial activity, and the extract obtained using higher extraction temperatures (250 °C) and without the defatting step demonstrated the lowest minimum inhibitory concentration (MIC) values (1.17; 4.6; 0.59 mg/mL for K. pneumoniae, S. aureus and C. acnes, respectively). Codfish samples extracted at lower temperatures (90 °C) were the most effective anti-inflammatory agents (a concentration of 0.75 mg/mL reduced IL-8 and IL-6 levels by 58% and 47%, respectively, relative to the positive control). Threonine, valine, leucine, arginine and total protein content in the extracts were highlighted to present a high correlation with the reported bioactivities (R2 ≥ 0.7). These results support the potential application of extracts obtained from fishery industry wastes in cosmeceutical products with bioactive activities.
AB - The fishery industry generates large amounts of waste (20–75% (w/w) of the total caught fish weight). The recovery of bioactive compounds from residues and their incorporation in cosmetics represents a promising market opportunity and may contribute to a sustainable valorisation of the sector. In this work, protein-rich extracts obtained by high-pressure technologies (supercritical CO2 and subcritical water) from sardine (Sardina pilchardus) waste and codfish (Gadus morhua) frames were characterized regarding their cosmeceutical potential. Antioxidant, anti-inflammatory and antibacterial activities were evaluated through chemical (ORAC assay), enzymatic (inhibition of elastase and tyrosinase), antimicrobial susceptibility (Klebsiella pneumoniae, Staphylococcus aureus and Cutibacterium acnes) and cell-based (in keratinocytes-HaCaT) assays. Sardine extracts presented the highest antibacterial activity, and the extract obtained using higher extraction temperatures (250 °C) and without the defatting step demonstrated the lowest minimum inhibitory concentration (MIC) values (1.17; 4.6; 0.59 mg/mL for K. pneumoniae, S. aureus and C. acnes, respectively). Codfish samples extracted at lower temperatures (90 °C) were the most effective anti-inflammatory agents (a concentration of 0.75 mg/mL reduced IL-8 and IL-6 levels by 58% and 47%, respectively, relative to the positive control). Threonine, valine, leucine, arginine and total protein content in the extracts were highlighted to present a high correlation with the reported bioactivities (R2 ≥ 0.7). These results support the potential application of extracts obtained from fishery industry wastes in cosmeceutical products with bioactive activities.
KW - anti-ageing
KW - anti-hyperpigmentation
KW - anti-inflammatory activity
KW - antimicrobial activity
KW - antioxidant activity
KW - cosmeceuticals
KW - fish waste streams valorisation
UR - http://www.scopus.com/inward/record.url?scp=85140436952&partnerID=8YFLogxK
U2 - 10.3390/antiox11101925
DO - 10.3390/antiox11101925
M3 - Article
AN - SCOPUS:85140436952
SN - 2076-3921
VL - 11
JO - Antioxidants
JF - Antioxidants
IS - 10
M1 - 1925
ER -