Coronary microvascular dysfunction in hypertrophic cardiomyopathy: Pathophysiology, assessment, and clinical impact

Sílvia Aguiar Rosa, Luís Rocha Lopes, António Fiarresga, Rui Cruz Ferreira, Miguel Mota Carmo

Research output: Contribution to journalReview articlepeer-review

Abstract

Myocardial ischemia constitutes one of the most important pathophysiological features in hypertrophic cardiomyopathy. Chronic and recurrent myocardial ischemia leads to fibrosis, which may culminate in myocardial dysfunction. Since the direct visualization of coronary microcirculation in vivo is not possible, its function must be studied indirectly. Invasive and noninvasive techniques allow microcirculatory dysfunction to be evaluated, including echocardiography, magnetic resonance, positron emission tomography, and cardiac catheterization. Blunted myocardial blood flow and coronary flow reserve have been suggested to associate with unfavorable prognosis. Microcirculatory dysfunction may be one additional important parameter to take into account for risk stratification beyond the conventional risk factors.

Original languageEnglish
Article numbere12656
JournalMicrocirculation
Volume28
Issue number1
Early online dateSep 2020
DOIs
Publication statusPublished - Jan 2021

Keywords

  • hypertrophic cardiomyopathy
  • microcirculatory dysfunction

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