Contributing factors to the plasma albumin level at diagnosis of hematological malignancy

Kim Oren Gradel, Henriette Engberg, Fernando G Zampieri, Pedro Póvoa, Simone F Simonsen, Pernille Just Vinholt, Olav Sivertsen Garvik, Pernille S Ljungdalh, Henrik Frederiksen

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: Many factors contribute to the plasma albumin (PA) level. We aimed to quantify different factors' relative contribution to the PA level when diagnosing hematological malignancy (HM).

METHODS: The study was a population-based registry study including patients with HM in a Danish region. We applied multivariate linear regression analyses with C-reactive protein (CRP), WHO performance score (WHO-PS), age, sex, comorbidity, and HM type as exposures and the PA level on the day of the HM diagnosis (DX) as the outcome. The relative contribution of each exposure was determined as a percentage of the models' coefficient of determination (R2).

RESULTS: In total, 2528 patients with HM had PA measured on DX. In the model comprising all exposures, CRP contributed with 65.8% to the R2 of 0.389 whereas 3 variables (CRP, WHO-PS, HM type) together contributed with 96.1%. When CRP was excluded from the model, R2 declined to 0.215 and the WHO-PS contributed with 96%. Other models, including separate analyses for each HM type, corroborated these results, except in myeloma patients where WHO-PS contributed with 61.1% to the R2 of 0.234.

CONCLUSION: The inflammation biomarker CRP was the main predictor of the PA level on DX. The WHO-PS also contributed to the PA level on DX whereas the remaining factors (HM type, age, sex, and comorbidity) were of much less importance.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalHospital practice (1995)
DOIs
Publication statusE-pub ahead of print - 2 Jun 2020

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    Gradel, K. O., Engberg, H., Zampieri, F. G., Póvoa, P., Simonsen, S. F., Vinholt, P. J., Garvik, O. S., Ljungdalh, P. S., & Frederiksen, H. (2020). Contributing factors to the plasma albumin level at diagnosis of hematological malignancy. Hospital practice (1995), 1-7. https://doi.org/10.1080/21548331.2020.1770511