Vitamin E in polycaprolactone nanoparticles was continuously produced by supercritical fluid extraction of emulsions using a high-pressure packing column in countercurrent mode. This operating mode reduces the amount of solvent required, increases production capacity and enables lower residual organic solvent concentrations in the raffinate. At 8.0ï¿½MPa and 313ï¿½K, with a packing height of 2ï¿½m, and a solvent to feed ratio of 5ï¿½kgï¿½L−1, the residual acetone concentration was 1400ï¿½ppm, far below 5000ï¿½ppm, and therefore suitable for pharmaceutical applications. The process was also simulated with Aspen Plus. It would be necessary to increase the packing height to 3.5ï¿½m or the CO2flow rate to 60ï¿½gï¿½min−1in order to get a residual acetone concentration suitable for food applications (50ï¿½ppm). The nanoparticles produced were non-aggregated spheres, which had an encapsulation efficiency higher than 70% and particle size at the nanoscale.
- Aspen Plus Simulation
- Continuous process
- Countercurrent packed column
- Supercritical fluid extraction of emulsions
- Vitamin E nanocapsules