Continuous supercritical fluid extraction of emulsions to produce nanocapsules of vitamin E in polycaprolactone

Cristina Prieto, Lourdes Calvo, Catarina M.M. Duarte

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Vitamin E in polycaprolactone nanoparticles was continuously produced by supercritical fluid extraction of emulsions using a high-pressure packing column in countercurrent mode. This operating mode reduces the amount of solvent required, increases production capacity and enables lower residual organic solvent concentrations in the raffinate. At 8.0�MPa and 313�K, with a packing height of 2�m, and a solvent to feed ratio of 5�kg�L−1, the residual acetone concentration was 1400�ppm, far below 5000�ppm, and therefore suitable for pharmaceutical applications. The process was also simulated with Aspen Plus. It would be necessary to increase the packing height to 3.5�m or the CO2flow rate to 60�g�min−1in order to get a residual acetone concentration suitable for food applications (50�ppm). The nanoparticles produced were non-aggregated spheres, which had an encapsulation efficiency higher than 70% and particle size at the nanoscale.

Original languageEnglish
Pages (from-to)72-79
Number of pages8
JournalJournal of Supercritical Fluids
Volume124
DOIs
Publication statusPublished - 1 Jan 2017

Keywords

  • Aspen Plus Simulation
  • Continuous process
  • Countercurrent packed column
  • Supercritical fluid extraction of emulsions
  • Vitamin E nanocapsules

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