Computed tomography (ct) perfusion: Basic principles and clinical applications

Joana N. Ramalho, Isabel R. Fragata

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


This chapter discusses the basic principles and clinical applications of computed tomography perfusion (CTP). Analysis of CTP can be based on visual interpretation of perfusion maps or on quantitative perfusion measurements. CT perfusion is clearly a viable alternative to other imaging perfusion modalities. It can be performed quickly with any standard spiral CT scanner, and the perfusion maps can be generated in a short time at the workstation. CT perfusion provides quantitative information on cerebral blood flow (CBF) parameters. It has been validated in many clinical situations against established techniques. The chapter reviews the most frequent clinical applications of the technique, along with some future trends. CTP has been used in a number of applications, notably in acute stroke. CTP techniques have also been applied to brain tumors. CTP has been recently applied to other disease processes, such as normal pressure hydrocephalus, trauma, epilepsy, and arterio-venous malformations.

Original languageEnglish
Title of host publicationVascular Imaging of the Central Nervous System
Subtitle of host publicationPhysical Principles, Clinical Applications and Emerging Techniques
Number of pages20
ISBN (Electronic)9781118434550
ISBN (Print)9781118188750
Publication statusPublished - 30 Nov 2013


  • Acute stroke
  • Brain tumors
  • Cerebral blood flow (CBF)
  • Computed tomography perfusion (CTP)
  • Normal pressure hydrocephalus
  • Trauma


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