TY - JOUR
T1 - Comparative in vitro activity of phenothiazines against multidrug- resistant Mycobacterium tuberculosis
AU - Bettencourt, Miguel Viveiros
AU - Bosne-David, Suzana
AU - Amaral, Leonard
PY - 2000/9
Y1 - 2000/9
N2 - The comparative activity of five phenothiazines against multidrug- resistant strains of Mycobacterium tuberculosis (MDRTB) was studied using the Bactec 460 system. The order of antimycobacterial activity of the phenothiazines was: chlorpromazine = thioridazine > promethazine > promazine = desipramine. However, the levels required for an MIC 50 exceeded 1 mg/l and are beyond those that are clinically achievable. As phenothiazines are concentrated by macrophages that phagocytose and have in situ activity against mycobacteria, these agents may be considered for use as adjuvants for the management of freshly diagnosed tuberculosis in patients from populations with a high prevalence of MDRTB. (C) 2000 Elsevier Science B.V. and International Society of Chemotherapy.
AB - The comparative activity of five phenothiazines against multidrug- resistant strains of Mycobacterium tuberculosis (MDRTB) was studied using the Bactec 460 system. The order of antimycobacterial activity of the phenothiazines was: chlorpromazine = thioridazine > promethazine > promazine = desipramine. However, the levels required for an MIC 50 exceeded 1 mg/l and are beyond those that are clinically achievable. As phenothiazines are concentrated by macrophages that phagocytose and have in situ activity against mycobacteria, these agents may be considered for use as adjuvants for the management of freshly diagnosed tuberculosis in patients from populations with a high prevalence of MDRTB. (C) 2000 Elsevier Science B.V. and International Society of Chemotherapy.
KW - In vitro activity
KW - Multidrug-resistant
KW - Mycobacterium tuberculosis
KW - Phenothiazines
UR - http://www.scopus.com/inward/record.url?scp=0033839994&partnerID=8YFLogxK
UR - https://www.sciencedirect.com/science/article/abs/pii/S0924857900001990?via%3Dihub
U2 - 10.1016/S0924-8579(00)00199-0
DO - 10.1016/S0924-8579(00)00199-0
M3 - Article
C2 - 11185417
AN - SCOPUS:0033839994
SN - 0924-8579
VL - Vol. 16
SP - 69
EP - 71
JO - International Journal Of Antimicrobial Agents
JF - International Journal Of Antimicrobial Agents
IS - n.º 1
ER -
