Communication: Site-selective bond excision of adenine upon electron transfer

T. Cunha, M. Mendes, F. Ferreira Da Silva, S. Eden, G. García, P. Limão-Vieira

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

This work demonstrates that selective excision of hydrogen atoms at a particular site of the DNA base adenine can be achieved in collisions with electronegative atoms by controlling the impact energy. The result is based on analysing the time-of-flight mass spectra yields of potassium collisions with a series of labeled adenine derivatives. The production of dehydrogenated parent anions is consistent with neutral H loss either from selective breaking of C-H or N-H bonds. These unprecedented results open up a new methodology in charge transfer collisions that can initiate selective reactivity as a key process in chemical reactions that are dominant in different areas of science and technology.

Original languageEnglish
Article number021101
JournalJournal of Chemical Physics
Volume148
Issue number2
DOIs
Publication statusPublished - 14 Jan 2018

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